Learn Psychedelic mushroom dose, safety tips, effects, and how they effect the brain. เห็ดไซโลไซบิน Mushroom Q&A เห็ดไซเคเดลิก คืออะไร เห็ดไซโลไซบิน (Psilocybin mushrooms) หรือที่รู้จักกันทั่วไปในชื่อ "เห็ดวิเศษ" (Magic mushrooms) หรือ "Shrooms" เป็นเชื้อราชนิดหนึ่งที่มีฤทธิ์ทางจิตประสาท (Psychedelic) ทำให้เกิดภาพหลอน รวมถึงส่งผลให้กระบวนการคิดและการรับรู้เปลี่ยนแปลงไป ซึ่งมีลักษณะคล้ายคลึงกับผลของ LSD เป็นอย่างมาก เห็ดกลุ่มนี้จัดเป็นสารหลอนประสาทที่ออกฤทธิ์ยาวนาน โดยกระบวนการเริ่มจากการเพาะปลูกและนำไปตากแห้ง จากนั้นจึงบริโภคด้วยการเคี้ยวทานโดยตรง หรือนำไปผสมในชา ช็อกโกแลต หรือบรรจุเป็นยาแคปซูล ในแง่ของการเสพติด เชื่อกันว่าเห็ดวิเศษไม่ก่อให้เกิดภาวะเสพติด (Non-addictive) ซึ่งเป็นลักษณะเดียวกันกับสารกลุ่ม LSD และ DMT Doses & effects are mushrooms addictive? How illegal are mushrooms? เชื่อกันว่าเห็ดวิเศษไม่ทำให้เสพติด เช่นเดียวกับ LSD และ DMT การเสพติด” มีสองประเภท คือ การพึ่งพาทางจิตใจ และการพึ่งพาทางร่างกาย เห็ดขี้ควายเป็นยาที่อาจทำให้เกิดการพึ่งพาทางจิตใจได้ แต่ไม่สามารถทำให้เกิดการพึ่งพาทางร่างกายได้ การเสพติดทางจิตใจ การเสพติดทางจิตใจเกิดขึ้นเมื่อบุคคลหนึ่งรู้สึกเพลิดเพลินกับความรู้สึกของยาเสพติด ความรู้สึกเพลิดเพลินดังกล่าวทำให้พวกเขายังคงเสพยาต่อไปเพื่อสร้างความรู้สึกแบบเดิมซ้ำ คนที่ชอบเสพเห็ดอาจยังคงเสพเห็ดต่อไปเพราะพวกเขาชอบความรู้สึกนั้น การใช้เห็ดอย่างต่อเนื่องอาจถือเป็นการเสพติดทางจิตใจได้ หากมีการใช้ที่มากเกินพอดีจนส่งผลเสียต่อสุขภาพ การทำงาน การเรียน หรือชีวิตเข้าสังคม นอกจากนี้ การเสพติดทางจิตใจยังพบบ่อยในผู้ที่มีภาวะซึมเศร้า (Depression) วิตกกังวล (Anxiety) รวมถึงผู้ที่มีปัญหาทางสุขภาพจิตหรืออารมณ์อื่นๆ การใช้ยาซ้ำๆ เพื่อหลีกหนีจากโลกแห่งความจริงหรือหนีปัญหาชีวิต อาจถือได้ว่าเป็นภาวะพึ่งพิงทางจิตใจ (Psychological dependence) ติดยาเสพติดทางกายภาพ The negative withdrawal symptoms are the body's response to t he drug missing. Intense cravings, physical symptoms such as anxiety, sweating, restlessness, and other feelings similar to the flu are common. Someone who takes magic mushrooms very frequently will need to keep increasing the dose for the trip to be as strong as the first few times. When heavy mushroom use is stopped there may be some desire or low level cravings to use the drug again but mushrooms are not able to cause physical withdrawal like feelings of being sick including sweating, anxiety, restlessness, etc. Onset – occurs in an hour and continues for 2 hours after ingestion Peak (strongest effects) – 3 hours after ingestion Come down (effects slowly waring off) hour 4 to 5 “afterglow” (lingering positive mood) – can last for 2 to 3 hours after effects have worn off Microdosing (0.1 to 0.25 grams) no psychedelic effects (visual) and only minor mood lifting occurs. The microdose level only influences subconscious emotion, thinking, and perception. Many believe microdosing often increases both productivity and creativity and may have anti-depressent effects. The benefits are being researched but no definitive conclusions about risk and reward can be given without thorough research. Very low dose (0.5 to 1 grams) Minor effects (visual) may occur. Colors may seem brighter and mood heightens. This dose is low and it is possible that psychedelic effects are not noticed depending on the person. It is very recommended to start at this dose if you are new to mushrooms or psychedelics in general. Low to moderate dose (1 to 2 grams) above 1 gram the effects will become noticeable visual hallucinations like colors and patters will become apparent and increase in intensity as the dose increases after 1 gram. Wonder filled thoughts and feelings of stimulation begin to intensify at this dose. average dose (2.5 to 3.5 grams) 3.5 grams is believed to be the perfect dose for full effects while remaining controllable and not too intense for most people. At 3.5 grams, colors and patterns are very noticeable and occur when eyes are both open and closed. Objects can “breath” which means swaying and bending in a magical type way. Vibrancy of colors is heightened and colors of the rainbow create complex shapes when eyes are closed. Intense feelings of stimulation and alertness. Thoughts and perception are extremely altered compared to sober. Anxiety and feelings of being overwhelmed are definitely possible but this dose cannot cause any physical harm and will not last forever. Very heavy dose (4.5 grams and above) heavy dose often called “heroic dose” – 4.5 grams and over is very potent and marks the point where overly intense become more likely. The effects of 5 grams may be much too intense for any beginner or even lightly experienced tripper. At this dose the psychedelic visuals may distort and fill vision so intensely that it is difficult to see straight and identify things around you which is very dangerous. Thought loops are very common at this dose and negative loops including terror, paranoia, and detachment from reality may be overwhelming and cause outbursts or irrational actions. It is critical to have someone you trust who remains sober to keep you safe on a dose that large. Having an accurate gram scale and a trip sitter is very important for any mushroom trip especially a stronger one. How much shrooms to take It is crucial to test dose (take 0.1 to 0.5 grams) every batch of mushrooms to test their strength. It is possible that 1 species of mushroom can be 10 times stronger than a different species. While 3.5 grams is the average, it is highly recommended to treat every type of mushrooms as if they are extremely potent and slowly increase the dose. The mushroom trip experience is very profound and intense even at normal dosages of 3.5 grams with average potency mushrooms. A normal dose takes between 15 minutes and an hour to start kicking in. The come up process occurs for about 2 hours since ingestion and the strongest effects occur from about hour 3 to hour 4 after ingestion. The peak of effects lasts about an hour and can cause strong time distortion, speeding up or slowing down perception of time. Fluid colors and object distortion can occur where objects seem to be swaying or “breathing.” Mushroom effects will start fading an hour after the peak occurs and will be mostly gone In about 6 hours. Psychedelic mushrooms are a illegal schedule 1 drug in the United States. Schedule 1 drugs are considered to have no medical benefits and high potential for abuse. The scheduling of a drug is determined by the Drug Enforcement Administration (DEA) in America. Other schedule 1 drugs include heroin, marijuana, LSD, and ecstasy (MDMA). The scheduling of drugs in America is very controversial and the scheduling does not always align with the current scientific research regarding the danger and abuse potential of the substances. Mushroom Pharmacology How psychedelics effect the brain Mushrooms are a monoaminergic psychedelic that has a chemical structure very similar to the neurotransmitter (brain chemical) serotonin. This fungus is called “psilocybin” mushrooms because the chemical psilocybin is present in high concentrations. Mushrooms are not able to be injected, snorted, or dissolved in the mouth. The stems and caps of Mushrooms can only be eaten to be effective because of the metabolizing action necessary for the drug to work. Psilocybin present in mushrooms needs to be digested and metabolized into the chemical “psilocin” which is the actual molecule responsible for the psychedelic effects. Psilocybin is 4-phosphoryloxy-dimethyltryptamine . When ingested, the liver breaks off the phosphate group and the molecule Psilocin is created (4-hydroxy-dimethyltryptamine ). Psilocin crosses the blood-brain barrier and binds to different serotonin receptors mainly the 5HT2A receptor. Are mushrooms similar to LSD? Psychedelic mushrooms function very similarly to LSD in the brain but mushrooms have a shorter duration compared to LSD because Psilocin molecules spend less time activating the serotonin receptors and are broken down faster than LSD. The most notable difference between LSD and Psilocybin mushrooms is the length of trip and subjective visual distortion differences. LSD visuals are often explained as geometric and rainbow whereas mushroom visuals are often described as more fluid and wavy. LSD is more straight lines and geometric shapes and mushrooms are more wavy lines and melting/flowing colors. But the mechanism of action in the brain between LSD and Mushrooms are very similar pharmacology wise. Chemical reaction in the liver Dihydrogen Phosphate group is removed and psilocin is formed. Psilocin is the active ingredient that activate serotonin receptors in the brain

DrugSpeak teaches legal and illegal drugs dosing, effects, and how to stay safe. ชุดน้ำยาทดสอบสาร Read more เห็ดไซโลไซบิน Read more แอลเอสดี Read more ดีเอ็มที Read more เอ็มดีเอ็มเอและยาอี Read more โคเคน Read more เมทแอมเฟตามีนและแอมเฟตามีน Read more Common Questions Quick answers

Learn all about the psychedelic drug ayahuasca containing DMT. How to use it, how to stay safe, and how it works in the brain and body. Ayahuasca DMT home page Ayahuasca is a brewed liquid traditionally from root bark and plants that contain DMT. Ayahuasca has a long history of use by South American religious groups as a sacred ritual where ayahuasca (DMT) drinks are consumed to cause psychedelic and spiritual experiences. The word ayahuasca is the name of a vine from the Amazon that contains DMT. While there are many plants used for ayahuasca a popular source of DMT is from the root bark of the plant Mimosa Hostilis. Mimosa Hostilis root bark is boiled which extracts the DMT from it. Drinking DMT root bark tea by itself will not give psychedelic effects. DMT is not an orally active molecule which is why the powder is often smoked. To make DMT tea orally active there must be a Monoamine oxidase inhibitor (MAOI) present. The liver enzyme Monoamine Oxidase breaks the DMT molecule down into a non-psychoactive derivative before it has a chance to cause psychedelic effects. Many metabolites are produced from DMT break down but mainly DMT-N-oxide (DMT-NO), and indole-3-acetic acid (IAA) which are not hallucinogenic. To prevent DMT breakdown in the liver the monoamine oxidase (MAO) must be blocked by way of a monoamine oxidase inhibitor (MAOI). Many ayahuasca brews contain both a bark like Mimosa Hostilis and a plant containing MAOIs such as Banisteriopsis caapi (BC) and Peganum harmala (PH). Both MAOI plants contain an active monoamine oxidase inhibitor such as β-carbolines harmalol, harmine, and harmaline. By brewing a DMT-containing bark like Mimosa Hostilis and MAOI-containing plant such as Peganum harmala together the resulting brew will cause hallucinogenic DMT effects when consumed. DMT containing plants such as Mimosa hostilis root bark are usually legal to purchase and possess in the united states. Although pure DMT powder is a schedule 1 illegal drug there is a grey area in the law about the entire plant. Purchasing and possessing the plant or bark is legal while extracting and consuming DMT is illegal. Mimosa hostilis root bark (contains DMT) Banisteriopsis caapi vine (contains MAOI inhibitor) Finished product: ayahuasca brew (contains DMT and MOAI inhibitor)

Learn about DMT. How to use it, how to stay safe, and how it effects the brain Pharmacology DMT Q&A DMT is often called “the spirit molecule” It is thought to be the most potent psychedelic drug known to science. DMT induces full out of body experiences known as ego death where the ability to realize you are alive or have lived is lost. DMT safety and dosing DMT stands for Dimethyltryptamine and 5-MeO-DMT is 5-methoxy-dimethyltryptamine. DMT is much stronger and lasts much less time than other psychedelics like LSD or mushrooms. The dosing guidelines provided below are for smoking DMT. Disclaimer: the dosage guidelines provided are extremely rough estimates and are not concrete. Variables such as purity, person's weight, and brain chemistry differences can all affect how DMT affects you at a certain dose. Use the dosages provided as a general idea and ALWAYS START SMALL and work your way up. There are defined levels and terminology for DMT trips. The difference between 30 and 40 mg of DMT powder causes a much stronger experience and is not noticeable to the naked eye. You must use a high quality milligram scale to safely dose this drug. DMT is often sold as a crystal or powder and is often smoked. Many people choose to put DMT onto marijuana and smoke it but that is not recommended as mixing marijuana with psychedelics raises the chances of having an overwhelming trip. DMT crystals are can be completely white but impurities in powders can cause an off-white, yellow, or light brownish color which is normal. Smoked DMT powder is often described as smelling and tasting like rubber or mothballs which is very distinct from any other smell. ayahuasca Dosing Pure DMT How illegal is DMT Ayahuasca is a brewed liquid traditionally from root bark and plants that contain DMT. Ayahuasca has a long history of use by South American religious groups as a sacred ritual where ayahuasca (DMT) drinks are consumed to cause psychedelic and spiritual experiences. The word ayahuasca is the name of a vine from the Amazon that contains DMT. While there are many plants used for ayahuasca a popular source of DMT is from the root bark of the plant Mimosa Hostilis. Mimosa Hostilis root bark is boiled which extracts the DMT from it. Drinking DMT root bark tea by itself will not give psychedelic effects. DMT is not an orally active molecule which is why the powder is often smoked. To make DMT tea orally active there must be a Monoamine oxidase inhibitor (MAOI) present. The liver enzyme Monoamine Oxidase breaks the DMT molecule down into a non-psychoactive derivative before it has a chance to cause psychedelic effects. Many metabolites are produced from DMT break down but mainly DMT-N-oxide (DMT-NO), and indole-3-acetic acid (IAA) which are not hallucinogenic. To prevent DMT breakdown in the liver the monoamine oxidase (MAO) must be blocked by way of a monoamine oxidase inhibitor (MAOI). Many ayahuasca brews contain both a bark like Mimosa Hostilis and a plant containing MAOIs such as Banisteriopsis caapi (BC) and Peganum harmala (PH). Both MAOI plants contain an active monoamine oxidase inhibitor such as β-carbolines harmalol, harmine, and harmaline. By brewing a DMT-containing bark like Mimosa Hostilis and MAOI-containing plant such as Peganum harmala together the resulting brew will cause hallucinogenic DMT effects when consumed. DMT containing plants such as Mimosa hostilis root bark are usually legal to purchase and possess in the united states. Although pure DMT powder is a schedule 1 illegal drug there is a grey area in the law about the entire plant. Purchasing and possessing the plant or bark is legal while extracting and consuming DMT is illegal. DMT is an illegal Schedule 1 drug in the United States. Schedule 1 drugs are considered to have no medical benefits and high potential for abuse. The scheduling of a drug is determined by the Drug Enforcement Administration (DEA) in America. Other Schedule 1 drugs include heroin, marijuana, and ecstasy (MDMA). The scheduling of drugs in America is very controversial and the scheduling does not always align with the current scientific research regarding the danger and abuse potential of the substances. DMT containing plants such as Mimosa hostilis root bark are usually legal to purchase and possess in the united states. Although pure DMT powder is a schedule 1 illegal drug there is a grey area in the law about the entire plant. Purchasing and possessing the plant or bark is legal while extracting and consuming DMT is illegal. An effective dose of DMT is very small and extremely potent so accurate measuring is crucial. You must use a scale that measures milligrams accurately and reliably. The average dose of smoked crystal (freebase) DMT is anywhere from 20 to 40 milligrams or 0.02 to 0.04 grams. Anything above 40 milligrams has a high chance of overwhelming the average person. DMT doses are so small that you must weigh them with a precision scale to remain safe and in control of your dose. For perspective, 50 milligrams is about how much a grain of rice weighs which is very small. Warning DMT carts are easily laced with deadly drugs like fentanyl. carts are the most dangerous way to ingest DMT How Ayahuasca is made Mimosa hostilis root bark DMT containing root bark is shredded and boiled to extract the psychedelic component Banisteriopsis caapi vine A monoamine oxidase inhibitor (MAOI) containing vine or bark is boiled with the DMT containing source to make the DMT orally active so psychedelic effects to occur when the brew is consumed Final product: ayahuasca The final brew contains orally active DMT which causes intense psychedelic effects when drank.

Learn how MDMA / ecstasy effect the brain from a simplified neuroscience perspective. MDMA Pharmacology MDMA Home page MDMA standing for Methylene-dioxy-methyl-amphetamine acts both as a psychedelic and stimulant in the catecholaminergic psychedelic class also known as phenylethylamine psychedelics and amphetamine stimulants. MDMA works by increasing synaptic concentration of serotonin, norepinephrine, and to a lesser extent, dopamine. When the MDMA molecule crosses the blood brain barrier the chemical is shaped similar enough to serotonin to enter a serotonin transporter. Then the MDMA molecules inhibit the vesicular monoamine transporters (VMAT) which causes serotonin to be rapidly released from the vesicles housing it and accumulates in the cytosol. Finally, MDMA changes the direction of serotonin transporters to release excessive amounts of serotonin out of the neuron which floods into the synaptic cleft. Serotonin reuptake is inhibited and leaves massive amounts of serotonin in the synaptic cleft to stimulate serotonin receptors continuously causing them to fire. MDMA mechanism in the brain

Learn about dosing, purity, and effects of cocaine. General Cocaine info Cocaine also known as coke, blow, and snow, is a stimulant powder that is inhaled through the nose (aka snorting). Cocaine has 2 common forms: powder that is snorted, and the crystal rock version called crack that is smoked. Both cocaine and crack contain the same psychoactive chemical. Snorted cocaine increases heart rate, blood pressure, and boosts general energy. Within a couple minutes of ingestion, the user feels a rush of euphoria and energy kick that feels very sharp and pleasurable. Many users often feel like they are stronger than they are, more confident, and more energetic. Users often speak quicker and move their body more via fidgeting or dancing if in a party or bar setting. Cocaine has a similar feeling to Adderall but much less duration and cocaine’s effects are felt much quicker than an Adderall pill. Cocaine Q&A pharmacology Cocaine is extracted from these leaves called Coca leaves It is critical to reagent test MDMA. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe cocaine vs crack How to dose cocaine How illegal is cocaine? Americans often view cocaine as a “high class” drug because of its high cost and history related to celebrities and wealthy people who use it. Many people believe that cocaine is a rich people’s party drug but crack is a drug that brings images of homelessness, addiction, hopelessness. This societal view is very dangerous as it downplays the dangers of cocaine use. It must be understood that powder cocaine and crack provide the exact same high and carry the same general dangers. The only difference between the two is that crack is smoked therefore the high feels more like a “rush” and effects are felt very quickly within 20 seconds. Cocaine Is snorted so the effects take a couple minutes to be felt which decreases the sense of quick euphoria. It is true that the rushing euphoria of crack is more psychologically addictive but both cocaine and crack have the exact same overall high. After all, crack is just powdered cocaine cooked together with baking soda to turn it into a crystal. American society has an inaccurate perception that cocaine is more socially acceptable than crack. Cocaine is an illegal Schedule 2 drug in the United States. Schedule 2 drugs are considered to have high potential for abuse with use potentially leading to severe psychological or physical dependence. The scheduling of a drug is determined by the Drug Enforcement Administration (DEA) in America. Other Schedule 2 drugs include Adderall, methamphetamine, and oxycodone, and fentanyl. The scheduling of drugs in America is very controversial and the ranking does not always align with the current scientific research regarding the danger and abuse potential of the substances. A dose of cocaine is often described one of two ways: bumps and lines. A “bump” is a smaller dose than a line where someone uses a tool like a key to pick up a little pile of powder and snorts it. The other way is a line where a larger dose of cocaine is placed on a surface like a table and snorted along the length of the line. The weight of a bump or line cannot be recommended because the purity of different people’s cocaine will be different. A 10 milligram bump of 100% pure cocaine is 4 times as strong as 25% pure coke so there really is no average size dose of cocaine. As a rough guide, always assume your cocaine is really strong so you do not underestimate it and take too much. Both powder cocaine and crack cocaine are very hard to dose correctly. Many factors such as purity, other adulterants (laced) or inaccuracies in weighing all make a recommendation for dosing extremely difficult. Since Cocaine is just a generic looking white powder it is nearly impossible to understand what the powder is made of by taste or smell alone. It is always urgently recommended to reagent drug test your substances before use. In America, Cocaine is heavily adulterated and cut with chemicals to thin it out or laced with other drugs to enhance the effects. Inactive ingredients like baking soda, baby powder, creatine, or lidocaine/ procaine, or a number of others are almost always added before a customer receives it. While active ingredients are less frequent it is adds risk and harm potential, cocaine is sometimes cut with caffeine, meth, and even opioids like heroin or fentanyl. Since all the inactive and active ingredients listed above could be generic white powders you can never be sure what is in cocaine. Pure cocaine and lethal dose fentanyl laced powder look the exact same. Furthermore, when adulterants are mixed with cocaine, most cutting agents are odorless so both look and smell are not able to be noticed. Fentanyl, caffeine, meth, are odorless when mixed with cocaine so a white powder called cocaine can really be made of anything. Cocaine is produced majorly in south America then trafficked to everywhere else in the world. Countries like Colombia, Bolivia, and Peru all have a monopoly on the cocaine production market. Cartels within those countries account for nearly 100% of the cocaine produced and distributed around the world. Although, cocaine in those countries is produced pure without adulterants, once that pure powder gets trafficked to another country the drug is cut and altered each time it changes hands. While America and Europe are both different distances from South America, the cutting agents used are largely the same. These substances include acetaminophen, phenacetine, caffeine, lidocaine and in almost 70% of the samples levamisole (363 out of 524 samples) dangers of Mixing cocaine and alcohol Cocaine is often a party drug used at clubs, festivals, and parties. Partiers that drink alcohol often use cocaine at the same time to diminish the sedative effects of alcohol and make them more alert. Mixing cocaine with alcohol is dangerous for many reasons. Firstly, alcohol is a depressant and cocaine is a stimulant so mixing them can make the user feel more sober than they actually are. Cocaine use while drinking can make someone feel as if they can drink more without getting sick or “blacking out.” This makes alcohol poisoning and injury from falling much more likely. Secondly, mixing cocaine and alcohol creates a very unique chemical reaction in the body. Mixing these drugs creates the psychoactive chemical cocaethylene in the body. Cocaethylene causes the euphoric effects of cocaine to increase and create severe toxicity in the cardiovascular system. Since alcohol is a depressant it causes the cardiovascular system to relax and dilates blood vessels including the vessels in the nose. Dilated nose blood vessels means that more of the cocaine snorted will reach the blood stream and heighten the drug effects even more. Cocaethylene is extremely toxic and more damaging than either cocaine or alcohol by themselves. The damage caused by alcohol plus cocaine plus cocaethylene makes this drug combination one of the most dangerous and toxic there is. cocaine main page toxicity and overdose potential of cocaine Cocaine overdose is quite common for a multitude of reasons. Coke is a strong nervous system stimulant which ramps up heart rate, metabolism, temperature, and blood pressure. If too much cocaine is consumed the spike in bodily functions may cause overexertion of organs causing heart attack, overheating (heat stroke), lung problems like pneumonia, and sleep deprivation in chronic users. Seizures are also possible due to cocaines stimulating effects in the brain. Cocaine outside of production countries such as Bolivia and Colombia is often cut with various things to mimic the effects of cocaine or thin the drug out. Everything from baby powder to lidocaine to fentanyl can be mixed into cocaine powder because all those substances are white powders visually identical to the pure drug. As with every other drug, it is heavily recommended to reagent test the substance to identify the chemicals and drugs it is made of. Reagent testing kits are fairly inexpensive yet they can save your life and spare your from ingesting a drug laced with something deadly like fentanyl. The Marquis and Liebermann reagent tests are recommended for cocaine testing. The marquis reagent can identify cocaine mixed with amphetamines Morris, Marquis, and Liebermann reagents. These kits that are capable of detecting specific cuts (levamisole and lidocaine) It is critical to reagent test Cocaine. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe How to reagent test Cocaine Reagent testing cocaine step 1 Morris reagent Real cocaine causes a blue color when it comes in contact with the morris reagent Any other color besides blue indicates the powder may be laced with another drug. Morris reagent is a 2 step process with 2 liquids used at the same time on the same sample. Reagent testing cocaine step 2 Marquis reagent This reagent does not confirm the sample is cocaine. It is meant to show you possible drugs laced into the powder. The marquis reagent must be used with step 1 and 3 to be confident. Reagent testing cocaine step 3 Liebermann reagent Real cocaine causes a yellow tan color Note that ketamine also has the same color. The Morris reagent (step 1) can distinguish ketamine from cocaine. Final Step ALWAYS USE A FENTANYL TESTING STRIP Use a fentanyl test for every drug you intend to take. it will save your life.

learn to use MDMA correctly and health consciously while having fun. How to use MDMA / ecstasy safely MDMA home page It is critical to reagent test MDMA / esctasy. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe MDMA use comes with many risks such as overdose, strain on the body, addiction potential. Firstly, the most common risk during MDMA use is the high likelihood of extreme overexertion. Molly causes feelings of energy and desire to keep moving. It is easy for those under the influence to dance too much, sleep too little, and neglect their bodies reactions. You body may give you signs of fatigue that would be noticeable when sober but MDMA may make you unaware that your heart rate is extremely high, very dehydrated, and very hot. Heat stroke, heart attack, and lethal dehydration are greatly increased while using MDMA. Since this drug is often used at concerts, raves, or clubs the users are often moving around a lot and possibly in the sun at a festival. It is crucial to remind yourself that you may be unaware of the strain your body is going through. Just because you do not feel tired that doesn’t mean you are ok to keep dancing for hours and hours on end in the sun. MDMA makes you feel such a way that blinds you from your bodies own signs telling you to do something like sit down or drink water. It is critical to chemical test your MDMA to confirm you have the correct drug. Drug reagent testing MDMA is extremely recommended because it can save your life. Molly is a very commonly “faked” or cut with other drugs like designer drugs, bath salts (cathinones) and methamphetamine. Many drugs such as MDA, 5-APB, meth, and various cathinones: Methylone, mephedrone, and N-ethyl-pentylone. The extensive list of shows the many possible “imposter substances” than can be sold as MDMA. It is very possible that a dealer does not truly know what their “ecstasy” is made of so reagent testing is absolutely essential before ingesting any form of supposed MDMA. It is recommended to use both the Marquis and Simons reagent testing kits on MDMA. By using a very small sample of the crystal or pill, using just a drop of the reagent reacts with the chemical on the sample and changes colors based on a chemical reaction. If the crystal or pill contains MDMA then the Marquis reagent can tell you the presence of MDMA or similar drugs like MDA which is a designer drug commonly used to make fake Ecstasy. Then using the Simons reagent can differentiate the presence of MDMA and other imposter substances. It is best to use a couple reagents instead of one to double check for other reactions that can indicate other substances present in the pill. It should be noted that reagent testing CANNOT tell you the strength of the pill it only tells you the presence of chemicals in it. So if the Marquis reagent indicates MDMA in the pill it can mean there is anything between 1/10th of a dose up to 5 doses, there is no way to know without thorough laboratory testing. Just because a reagent indicates that MDMA is in the pill it does not mean it is a safe dose, so always start with a test dose and build your way up to prevent a possible overdose. Users often dangerously mix MDMA with other drugs to enhance the trip and euphoric feelings. MDMA is sometimes mixed with the psychedelic 2C-B called “Nexus Flipping” or MDMA and LSD called “candy flipping.” Mixing 2 or more psychedelic or stimulant drugs can be very dangerous as the effects become more unpredictable and can synergize the drug’s effects making overdose or overstimulation much more likely. One possible risk of mixing 2 psychedelics together is serotonin syndrome. Serotonin syndrome is a complication when serotonin levels in the brain are too high and the body cannot counteract it. Mixing 2 drugs that influence serotonin such as antidepressants and MDMA can cause large amounts of serotonin release and too little reuptake which overloads the serotonin receptors. Serotonin syndrome symptoms include muscle spasms, severe confusion, seizures, hyperventilation, and in very severe cases death by heart attack. Serotonin syndrome is very serious and should be considered before deciding to mix 2 or more psychedelic drugs. Anything that effects serotonin risks serotonin syndrome, everything from antidepressants, LSD, MDMA, psilocybin mushrooms, amphetamines, and opioids as well. Other than serotonin syndrome the individual effects of each additional drug can present danger. MDMA is known to increase blood pressure, heart rate, and body temperature. MDMA effects mixed with another stimulant like amphetamines (Adderall, speed, meth) which also cause increased heart rate can put excessive stress on the body and increase likelihood of heart attack, seizure, stroke, and overheating. MDMA / ecstasy is a very powerful drug and consuming other substances with it should be avoided or very cautiously dosed and thought out at the very least. Next page

Learn how amphetamines effect the brain from a simplified neuroscience perspective Meth and adderall pharmacology It might be suprising to some but meth and adderall work the EXACT SAME WAY in the brain everything written below applies to both meth and adderall equally main page American society often associates methamphetamine with addiction, death, overdose, and crazy people. Adderall is viewed as a medicine good for studying and productivity at work. Pharmacology research and chemical analysis shows that methamphetamine and Adderall are the EXACT SAME DRUG when it comes to addiction potential, psychoactive effects, as well as mental damage. All scientific literature you can find online will tell you the chemical structures are 99% similar and the 1% difference goes away one once the drug is ingested in any form. The images below displays the similarities. Amphetamine base chemical name is alpha-methylphenethylamine Crystal Methamphetamine is a hydrochloride salt Adderall is a mixture of levoamphetamine and dextroamphetamine Amphetamines bind to presynaptic membrane of dopaminergic neurons and release massive amounts of dopamine especially in the striatum. Then amphetamine molecules bind to dopamine reuptake transporters which prevents dopamine from leaving synaptic gap and reversing dopamine transporters which causes free dopamine to be transported out of the terminal. High doses of amphetamines even cause monoamine oxidase inhibition which prevents dopamine, epinephrine, norepinephrine, and serotonin breakdown. Inhibiting monoamine oxidase increases all monoamine prevalence and receptor interactions. Chemical comparison Amphetamine (Adderall) only has 1 more hydrogen and 1 less methyl group (CH3) than meth. Next page Our Clients

Learn LSD pharmacology from a simplified neuroscience perspective. Pharmacology of LSD Learn how LSD works in the brain from a molecular perspective Main LSD page Lysergic acid diethylamide (LSD) is a monoaminergic psychedelic with a chemical structure very similar to the neurotransmitter serotonin. Upon consumption, the LSD molecule crosses the blood-brain barrier and binds to 8 different serotonin receptors mainly the 5HT2A receptor. LSD binding agonizes (binds to) this receptor and causes an increase in 5HT2A serotonin firing. The proposed reason for LSD's lengthy duration is due to the formation of a "lid" on the serotonin receptor. It is believed that the LSD molecule creates a type of lid that hinders the reuptake of the molecule, making it more difficult for it to be broken down and removed from the serotonin receptor. This prolonged interaction with the receptor contributes to the extended effects of LSD compared to endogenous (naturally occurring) serotonin. Next page LSD analogues (drugs similar to LSD) LSD is illegal and completely unregulated since it is produced and distributed illegally the purity, dose, and substance is unknown when dealing with LSD. When people say LSD they mean the chemical Lysergic acid diethylamide. There are many analogues of LSD that are known and being researched. A drug analogue is a chemical that looks and behaves very similarly to another chemical while having very slight differences . For example, Lysergic acid diethylamide (LSD) has a very similar chemical called 1p-LSD. The 1p-lsd molecule looks nearly identical to someone without a background in chemistry but there is a slight difference between LSD and 1p-LSD. Both chemicals are psychoactive and cause psychedelic effects but LSD is schedule 1 illegal and 1p-LSD is considered a research chemical and not directly illegal. The Federal analogue act of 1986 in the United States stated that a chemical that is substantially similar to an illegal drug should be considered illegal as well but only if the chemical is intended for human consumption. Some research companies in Canada legally distribute analogues of LSD such as 1p-LSD, 1b-LSD, 1v-LSD. All these chemicals are very similar to LSD but not exactly the same. There are definitely differences between them but they are all psychedelic and are measured in microgram doses similar to Lysergic Acid diethylamide (regular LSD). (both tabs contain 1p-LSD) Sometimes analogues are on labeled blotter paper. Most analogues are meant to trick buyers into thinking it is real LSD. 1-propanoyl-lyserigic acid diethylamine Fun fact LSD was made on accident by Swiss scientist Albert Hoffman in 1943. He dosed himself by mistake and experienced the first LSD trip ever! ALBERT HOFFMAN: THE CREATOR OF LSD

Learn LSD dose, effects, safety tips, and how acid works in the brain. LSD LSD, also known as Acid & Lucy, is a very potent psychedelic drug that causes visual hallucinations and alters perception and mood. The acronym LSD stands for Lysergic acid diethylamide. LSD effects are similar to psilocybin mushrooms (magic mushrooms), as they both mimic the brain chemical serotonin. the duration of the trip lasts approximately 6 to 10 hours with the strongest effects occurring at 3 hours after ingestion. Pharmacology LSD tab dosing How to dose correctly What does LSD feel like? To safely ingest LSD it is crucial to understand that it is very potent even in low doses. A typical dose of LSD is 100 micrograms which is equivalent to 0.1 milligrams or roughly the size of a grain of sand. One tab can contain anywhere from 1 microgram to 500 micrograms. It is difficult to determine the correct dose of LSD because a couple grains of sand worth of LSD can turn a normal dose into an extremely strong one. Doses are sold in various forms including, blotter paper, gelatin tabs, or crystal LSD dissolved in alcohol known as a “vial.” It is not possible to precisely know how many micrograms are on a tab without lab testing so it is critical to take a test dose. Microdosing 1/20th to 1/10th of a tab no psychedelic (visual) effects but minor mood lifting may occur. The microdose level should only influence subconscious emotion, thinking, and perception. Many believe microdosing increases both productivity and creativity and has anti-depressent effects. The benefits are being researched but no definitive conclusions about risk and reward can be given without thorough research. Very low dose (1/10th to 1/5th of a tab Minor psychedelic (visual) effects may or may not occur. Colors may seem brighter and surfaces may have moving patterns covering them. Mood should be noticeably altered with increased deep thought and noticing details, colors, and surroundings like nature may be much different than sober perceptions. Low to moderate dose (1/4 to 1/5 of a tab) Effects will become very noticeable above a quarter tab. visual hallucinations like colors and patters will become apparent and increase in intensity as the dose increases after .25 tabs. Wonder filled thoughts and feelings of stimulation begin to intensify at this dose. Mood can increase with feelings of exitement and slight euphoria. Even a low dose can cause anxiety and sometimes fear if your mindset and location are not correct. Tripping in a very public place like a concert or crowded beach are more likely to cause anxiety compared to a calm house or soothing nature. normal dose (full psychedelic trip) 1 full tab 1 tab is designed to be the perfect dose for full psychedelic effects while usually remaining controllable and not too intense for. at 1 full tab the colors and patterns are very apparent and occur when eyes are both open and closed. Objects often “breath” which means swaying and bending in a magical type way. You may notice the floor, walls, trees, hands, and surfaces sway and have patterns overlayed on them. Vibrancy of colors is heightened and closed eye visuals contain all colors of the rainbow that create complex shapes and infinite kaleidoscopic patterns. Intense feelings of stimulation and alertness. Even though 1 tab is an average dose for a full trip there is still a chance that paranoia or anxiety can occur. The best way to prevent them is to take LSD with people you trust in a place that makes you calm / comfortable Very heavy dose (greater than 1 full tab) heavy doses above 1 full tab are very potent and marks the point where bad trips become more likely. The effects of 1.5 to 3 tabs may be much too intense for any beginner or even experienced people. At this dose the psychedelic visuals may distort and fill vision so intensely that it is difficult to see straight and identify things around you which is very dangerous. Thought loops are very common at these doses and negative loops including terror, paranoia, and detachment from reality may be overwhelming and cause outbursts or extreme confusion. It is critical to have someone you trust who remains sober to keep you safe on a dose that large. Ego death is possible when many tabs are taken at once. Ego death is when the trip is so strong you forget that you are alive and is similar to being in a trance. Time and reality and shattered and your actions and behavior may be out of your control. It is extremely risky to experience ego death alone, with strangers, or anywhere in public. To test the strength of a tab, it is advised to start by ingesting 10% of a tab to gauge the strength. 10% of a normal 100 microgram tab should not cause any visual distortions whatsoever. You may experience slight mood changes but such a low dose should cause very minimal noticeable effects. If visual effects are noticeable with 10% of a tab then the tab is much stronger than a standard dose. Once a low dose is tested you can help prevent taking too much in the future. If you are confident that 10% of a tab is not strong then slowly start increasing amount of dose up to a full tab. LSD can be absorbed in the mouth or digested in the stomach. The most effective method of ingestion involves placing the tab underneath the tongue then swallowing the paper 15 minutes later. Alternatively, the tab can be swallowed immediately but the psychedelic effects may be delayed a bit longer than the under the tongue method. After ingesting the tab, the effects should begin within 45 minutes. If there are no effects at all within 1.5 hours the tab is either very weak or did not contain LSD at all. DO NOT take another tab unless at least 2.5 hours have gone by with zero effects. You do not want to take another dose before the last one has gotten the full amount of time to onset. LSD Q&A Onset – occurs within an hour Intensity increase – hour 1 to 3 Peak - (strongest effects) – 3 hours after ingestion Come down - (effects slowly waring off) hour 4 to 8 "afterglow” - (lingering positive mood) – can last for 2 to 8 hours after effects have worn off How to see if your LSD is real It is critical to reagent test LSD. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe Reagent testing LSD step 1 Ehrlich reagent Real LSD causes a purple color when it comes in contact with the Ehrlich reagent Any other color besides purple indicates the tab does not contain LSD and may be laced with a different drug It is critical to reagent test your LSD to confirm you have the correct drug. Reagent testing LSD is extremely recommended because it can save your life. The “Ehrlich” reagent test is the preferred test for LSD. The Ehrlich reagent kit will reliably test blotter tabs of LSD. The Ehrlich reagent works by placing one drop of the reagent on about 1/20th of a blotter tab. The reagent reacts with the chemical on the tab and changes colors based on the chemical reaction. If the LSD is real then the Ehrlich reagent will yield a purple color within 5 seconds to 5 minutes. If there is no color or anything different than purple you cannot be certain your tab contains LSD and you should throw the tabs away. Reagent testing LSD step 2 Hoffman reagent Real LSD causes a blue color when it comes in contact with the Hoffman reagent NBOMe drugs are an LSD imposter substance that can kill you. Make sure the color is not yellow or amber colored. Those colors indicate a drug different than LSD and may be NBOMe drugs. (See 25D and 25B NBOMe in the image to the right). You must use the Hoffman reagent as well to test tabs. Hoffman reagent can detect the difference between real LSD and different variants of NBOME. The Hoffman reagent yields a blue color when it touches real LSD and different types of yellow or pink for other substances like 25i-nbome, 2c-I, and 25B-NBOME. There are similarities and very important differences between LSD and NBOME. LSD dose ranges from 40 micrograms (low) to 250 (high) with the average being 100 to 150 micrograms. Whereas NBOME doses are mild at 250 to 450 micrograms high doses are around 450 to 800 micrograms. The dosages between LSD and NBOME seem different in numbers but the difference of 200 micrograms to 600 is extremely small to the naked eye. Since it is nearly impossible to visually distinguish how much of a drug is on blotter paper or in a vial or gelatin tabs it is best to test the substance with an Ehrlich reagent kit. LSD by itself can not kill you by overdose but NBOME can kill you very easily. The worst that can happen in a high LSD dose is terror, anxiety, and confusion. But you will live and not experience noticeable brain damage even in extremely high doses. On the other hand, NBOME compounds can directly kill you LSD in any form like blotter paper, gelatin tabs, or liquid in a vial is tasteless and odorless. An LSD dose cannot be visually measured because 100 micrograms is microscopic. It is essential to be aware that street dealers may sell dangerous counterfeit substances presented as LSD. For instance, the psychedelic compound 25I-NBOMe is sometimes passed off as acid. However, NBOMe compounds are much more harmful than LSD, only a few grains of salt worth of NBOME compounds can lead to severe health complications, including heart failure, seizures, and death. LSD doses typically range from 40 micrograms (low) to 250 micrograms (high), with the average dose falling between 100 to 150 micrograms. In contrast, NBOMe doses are considered mild at 250 to 450 micrograms, with high doses reaching around 450 to 800 micrograms. While the microgram gap may seem large, in reality, a difference of 300 micrograms is extremely hard to visually notice while being much more powerful. Given that visually determining the quantity of a substance on blotter paper, in a vial, or gelatin tabs is virtually impossible, it is highly recommended to test the substance using an Ehrlich reagent kit. NBOMe compounds have the potential to cause lethal consequences. The lethal dose of NBOMe can be as little as 2 milligrams (2000 micrograms), which is a minuscule amount. What is LSD tolerance? LSD often carries misconceptions and negative stigma in the public eye. While all psychoactive substances carry risks, the level and nature of the risk vary between different drugs. LSD is widely recognized as having a very low potential for addiction. The low addiction risk is due to the unique tolerance built for LSD when used consistently. When is LSD used more than once a week tolerance builds up quickly, requiring higher doses to achieve the same effects. For example, if someone takes a 100 microgram tab of LSD every day for a week, by the seventh day, that same 100 microgram tab would have significantly diminished psychedelic effects, perhaps feeling like only 1.5 micrograms which has zero psychedelic effects. The drastic drop in effect makes LSD nearly impossible to become addicted to because you have to increase the dose to absurd levels. After a week of everyday use, someone would have to consume 128 tabs to feel average psychedelic effects. The number of LSD needed to be consumed is doubled each consecutive day it is used which makes the likelihood of someone becoming addicted to LSD extremely low. Similarly, there have been zero reliably recorded cases of LSD overdose caused solely by LSD in those without prior medical conditions or mixing other substances with LSD. 100 LSD gel tabs Gel tabs come in many different colors and shapes Color or shape do not indicate strength or purity 100 LSD blotter tabs Blotter tabs can have infinite amount of designs. The design does not indicate strength or purity