Learn how MDMA / ecstasy effect the brain from a simplified neuroscience perspective. MDMA Pharmacology MDMA Home page MDMA standing for Methylene-dioxy-methyl-amphetamine acts both as a psychedelic and stimulant in the catecholaminergic psychedelic class also known as phenylethylamine psychedelics and amphetamine stimulants. MDMA works by increasing synaptic concentration of serotonin, norepinephrine, and to a lesser extent, dopamine. When the MDMA molecule crosses the blood brain barrier the chemical is shaped similar enough to serotonin to enter a serotonin transporter. Then the MDMA molecules inhibit the vesicular monoamine transporters (VMAT) which causes serotonin to be rapidly released from the vesicles housing it and accumulates in the cytosol. Finally, MDMA changes the direction of serotonin transporters to release excessive amounts of serotonin out of the neuron which floods into the synaptic cleft. Serotonin reuptake is inhibited and leaves massive amounts of serotonin in the synaptic cleft to stimulate serotonin receptors continuously causing them to fire. MDMA mechanism in the brain

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DrugSpeak teaches legal and illegal drugs dosing, effects, and how to stay safe. Psilocybin-Pilze Mehr lesen Psilocybin-Pilze Mehr lesen LSD Mehr lesen DMT Mehr lesen MDMA und Ecstasy Mehr lesen Kokain Mehr lesen Meth und Adderall Mehr lesen Häufig gestellte Fragen Schnelle Antworten

learn to use MDMA correctly and health consciously while having fun. How to use MDMA / ecstasy safely MDMA home page It is critical to reagent test MDMA / esctasy. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe MDMA use comes with many risks such as overdose, strain on the body, addiction potential. Firstly, the most common risk during MDMA use is the high likelihood of extreme overexertion. Molly causes feelings of energy and desire to keep moving. It is easy for those under the influence to dance too much, sleep too little, and neglect their bodies reactions. You body may give you signs of fatigue that would be noticeable when sober but MDMA may make you unaware that your heart rate is extremely high, very dehydrated, and very hot. Heat stroke, heart attack, and lethal dehydration are greatly increased while using MDMA. Since this drug is often used at concerts, raves, or clubs the users are often moving around a lot and possibly in the sun at a festival. It is crucial to remind yourself that you may be unaware of the strain your body is going through. Just because you do not feel tired that doesn’t mean you are ok to keep dancing for hours and hours on end in the sun. MDMA makes you feel such a way that blinds you from your bodies own signs telling you to do something like sit down or drink water. It is critical to chemical test your MDMA to confirm you have the correct drug. Drug reagent testing MDMA is extremely recommended because it can save your life. Molly is a very commonly “faked” or cut with other drugs like designer drugs, bath salts (cathinones) and methamphetamine. Many drugs such as MDA, 5-APB, meth, and various cathinones: Methylone, mephedrone, and N-ethyl-pentylone. The extensive list of shows the many possible “imposter substances” than can be sold as MDMA. It is very possible that a dealer does not truly know what their “ecstasy” is made of so reagent testing is absolutely essential before ingesting any form of supposed MDMA. It is recommended to use both the Marquis and Simons reagent testing kits on MDMA. By using a very small sample of the crystal or pill, using just a drop of the reagent reacts with the chemical on the sample and changes colors based on a chemical reaction. If the crystal or pill contains MDMA then the Marquis reagent can tell you the presence of MDMA or similar drugs like MDA which is a designer drug commonly used to make fake Ecstasy. Then using the Simons reagent can differentiate the presence of MDMA and other imposter substances. It is best to use a couple reagents instead of one to double check for other reactions that can indicate other substances present in the pill. It should be noted that reagent testing CANNOT tell you the strength of the pill it only tells you the presence of chemicals in it. So if the Marquis reagent indicates MDMA in the pill it can mean there is anything between 1/10th of a dose up to 5 doses, there is no way to know without thorough laboratory testing. Just because a reagent indicates that MDMA is in the pill it does not mean it is a safe dose, so always start with a test dose and build your way up to prevent a possible overdose. Users often dangerously mix MDMA with other drugs to enhance the trip and euphoric feelings. MDMA is sometimes mixed with the psychedelic 2C-B called “Nexus Flipping” or MDMA and LSD called “candy flipping.” Mixing 2 or more psychedelic or stimulant drugs can be very dangerous as the effects become more unpredictable and can synergize the drug’s effects making overdose or overstimulation much more likely. One possible risk of mixing 2 psychedelics together is serotonin syndrome. Serotonin syndrome is a complication when serotonin levels in the brain are too high and the body cannot counteract it. Mixing 2 drugs that influence serotonin such as antidepressants and MDMA can cause large amounts of serotonin release and too little reuptake which overloads the serotonin receptors. Serotonin syndrome symptoms include muscle spasms, severe confusion, seizures, hyperventilation, and in very severe cases death by heart attack. Serotonin syndrome is very serious and should be considered before deciding to mix 2 or more psychedelic drugs. Anything that effects serotonin risks serotonin syndrome, everything from antidepressants, LSD, MDMA, psilocybin mushrooms, amphetamines, and opioids as well. Other than serotonin syndrome the individual effects of each additional drug can present danger. MDMA is known to increase blood pressure, heart rate, and body temperature. MDMA effects mixed with another stimulant like amphetamines (Adderall, speed, meth) which also cause increased heart rate can put excessive stress on the body and increase likelihood of heart attack, seizure, stroke, and overheating. MDMA / ecstasy is a very powerful drug and consuming other substances with it should be avoided or very cautiously dosed and thought out at the very least. Next page

Learn about Amphetamines, the dose, purity, effects, and how they work in the brain How to safely use meth and adderall (amphetamines) Meth & adderall Q&A Drugs list Amphetamine pharmacology Amphetamines are a group of stimulant drugs including Meth and Adderall. There are thousands of drugs in the amphetamine class but these 2 are the most prevalent in society. Methamphetamine and amphetamine salt (Adderall) yield extremely similar effects and carry similar risks when consumed in recreational doses. Note that any information written about ADDERALL refers to those who abuse and get high on it. Prescribed amounts for those who need the drug are not included in this article. People with ADHD taking prescribed 5mg to 20mg of Adderall are not the same as an average person snorting (sniffing) many crushed up pills to get high. Methamphetamine is also known as meth, crank, ice, crystal. Adderall is sometimes called a smart drug or study drug. Methamphetamine is illegal in all circumstances whereas Adderall can be legally prescribed for the treatment of disorders like attention deficit hyperactivity disorder (ADHD). Both drugs are central nervous stimulants or “uppers” that induce euphoria, explosive amount of energy, increase enthusiasm, ramp up heart rate, and constrict pupils / circulation. High doses of these drugs lessen the desire for eating or sleeping which has many mental and bodily consequences. The Amphetamine class of drugs used recreationally cause the user to feel stronger, more confident, smarter, and more aware then they really are. how illegal is meth / adderall meth & adderall myths The general population views meth as a hard drug that is highly addictive and ruins the life of everyone who uses it. Someone imagining a meth addict visualizes a bone skinny, raggedy, toothless, dirty homeless person. Meanwhile, when someone visualizes an Adderall user they often visualize a businessman taking drugs to manage their busy work or busy family schedule. Put simply, meth is viewed as a dangerous drug that ruins lives and Adderall as a drug used for studying and productivity for normal people. The truth, according to pharmacology, is that pure meth and Adderall are just as addictive and relatively the same danger level to consume when taken at the same dose. Both meth and Adderall equally cause sleep deprivation, weight loss, dopamine deficiency, and brain alterations. Both chemicals function the same way in the brain and carry extremely similar overdose potential. Society is mislead because meth is illegal and Adderall is a “medicine” so it is reasonable to believe that a medicine is good for you and illegal drugs are dangerous. Sadly, this is not the case. Adderall (dextro and levoamphetamine) is not a better or worse choice to make legal than using medical grade methamphetamine. The one and only reason Adderall may be considered a better option to use recreationally is because pills from a pharmacy are not likely to be laced, have impurities, and have accurate dosing. Theoretically, if you have 2 pills, one contains meth and the other contains Adderall amphetamines. Assume both are medical grade and contain no harmful additives. It would be impossible to tell which pill contains what based solely off of the effects of the drug. The only way to tell is if you test the pill with a reagent testing kit. Overall, it is highly recommended to learn about drugs on your own and not believe that legal medicines are always good and illegal drugs will always kill you. Adderall and meth are effectively the same drug with totally different public perceptions. Methamphetamine and Adderall are both Schedule 2 drugs in the United States. Schedule 2 drugs are considered to have high potential for abuse potentially leading to severe psychological or physical dependence. The scheduling of a drug is determined by the Drug Enforcement Administration (DEA) in America. Other Schedule 2 drugs include cocaine, Ritalin, oxycodone, and fentanyl. The scheduling of drugs in America is very controversial and the ranking does not always align with the current scientific research regarding the danger and abuse potential of the substances. Adderall dosing Instant release Tablets made of pressed powder effects last 4 to 6 hours usually lower dosages (5mg to 15mg) but sometimes higher dosages (30mg) Extended release capsules capsule full of amphetamine beads effects typically last 8 to 12 hours, possibly longer Higher dosages (20mg to 30mg) Adderall is available as either colored, stamped pills or orange capsules with beads. Pills provide immediate effects within an hour, while capsules offer extended release over 6urs. Some abuse Adderall by crushing snorting it, seeking a quicker rush of euphoria, which is dangerous. Snorting can harm the nose and respiratory system, as the fillers are not meant for inhalation, and it increases the drug's addictive potential due to the rapid onset of effects. Meth dosing Methamphetamine is often found in powder or crystalized form. Powder meth is often snorted, injected, swallowed in capsules. Whereas crystal meth is not snorted because it severely cuts and tears the inside of the nose. Crystal can be smoked, melted then injected, or swallowed. Due to meth being illegal and not created by a regulated company the ingredients in meth are unknown. It is recommended to swallow meth opposed to snorting, smoking, and definitely avoid injecting. Making meth includes using extremely toxic chemicals like strong acids, phosphorous and many dangerous chemicals that can damage your nose, lungs, and veins. It is extremely recommended to never do meth in any form but if you do meth it Is extremely recommended that swallowing an ACCURATELY WEIGHED small dose is the best way to avoid excess damage to internal organs. Administering meth in other ways than swallowing can lead to damage to nasal cavities, lungs, teeth, throat, and veins. The phrase “meth mouth” exists because people who smoke meth for a long time have severe tooth and gum damage. The actual methamphetamine drug itself does not cause mouth damage. It is the toxic additives that are leftover from creating the drug. How to remain safe using street Adderall Street Adderall are very commonly counterfeited, laced with meth or other drugs, and can contain the wrong dose. These risks apply to Adderall pills not from a pharmacy / prescription. The rule of thumb is if you did not personally pick them up from the pharmacy with your prescription then you MUST assume they are counterfeit. Never believe a dealer that say they got them from a pharmacy even if they show you a prescription. Always assume a dealers drugs will be laced . Dealers and producers can buy amphetamine powder and a pill press machine from amazon to make pills that looks identical to a real pharmaceutical grade pill. Do not try to visually distinguish real from fake pills. Additionally, if you test your Adderall and it tests positive for the correct drug, you can never know how much of the drug is in the pill. Never blindly believe the pills label If its stamped “30” or “15” indicating the amount of milligrams. Counterfeit dealers often press an incorrect amount of the amphetamine powder into the pill. There is not a test to determine how strong the pill is so after reagent testing the pill , it is recommended to swallow 10% of the pill to gauge how strong it is. Counterfeit Adderall often contain no Adderall at all. Many pills are made with powdered methamphetamine mixed with colored pill binder and pressed into the shape and color of real pills. Dealers can make more money selling meth and calling it Adderall. If you get Adderall pills from anywhere besides a pharmacy with your prescription you MUST reagent test the drug to make sure your pills are not methamphetamine. Many websites sell the test kits can decipher Adderall from meth It is critical to reagent test meth / Adderall. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe How to test if your Adderall is real Step 1 Buy the marquis OR Liebermann reagent. Either of these tests will turn orange when EITHER meth or Adderall is detected. The marquis / Liebermann test will tell you if you have a type of amphetamine and not a completely different drug like heroin or MDMA. Only Meth and Adderall turn orange when using this test. Step 2 Buy the Simon’s reagent to see if you have meth OR Adderall. When placing a drop of the simons reagent on a small portion of the pill, the reagent will turn blue if the pill is made of meth and have no reaction if the pill is Adderall. step 3 You must use a fentanyl contamination test. As little as 2 grains of sand worth of fentanyl can be deadly. This step is as important as the previous 2 steps. Information to note YOU MUST UNDERSTAND that both marquis OR lieberman in addition to simons need to be used. Using only 1 reagent and not the other will not give you enough information to confidently say the pill is meth or Adderall. After both steps of reagent testing it is likely that the results from the reagents determined the correct drug.

Learn MDMA dosing, purity, what it feels like, and how molly effects the brain. MDMA Pharmacology MDMA ecstasy MDMA Q&A MDMA introduction MDMA also known as ecstasy (XTC), molly, mandy, beans, and the love drug, is both a stimulant and psychedelic that causes euphoria, heightened energy, and increased empathy (wanting to be social and connected to others). MDMA stands for Methylene-dioxy-methyl-amphetamine. MDMA is chemically similar to Mescaline (psychedelic peyote cactus), and 2c-B. All these drugs act as a stimulant and a psychedelic simultaneously which increases the level of serotonin, epinephrine, and dopamine in the brain. These types of stimulating hallucinogens are called catecholaminergic psychedelics . High amounts of serotonin cause psychedelic effects and an increase in epinephrine or norepinephrine is responsible for the amphetamine-like energy boost. After all, the “A” in MDMA stands for amphetamine and the huge meth energy boost applies to MDMA users. MDMA aka Molly is the pure crystal version of the drug, the word “molecular” is shortened to "molly" to express that the drug is in its pure crystal form. The term "ecstasy" refers to the unpure pill form of the drug that contains MDMA crystals as well as fillers and colors to make the pill into a shape and different bright colors. In addition to fillers, ecstasy pills are often cut with other drugs like caffeine, meth, and synthetic cathinone known as “bath salts.” Ecstasy refers to colorful pills and MDMA (Molly) is the pure crystal that is snorted or swallowed. What is an MDMA hangover like An average dose lasts about 4 hours with the strongest effects occurring about 2 hours after ingestion. On a serious note, before trying MDMA for the first time, you must be aware of the MDMA “hangover.” Hangover is in quotations because people often assume it is similar to alcohol hangover but MDMA’s after-effects are completely different. MDMA “hangover” is extremely severe compared to any other psychedelic. Since MDMA releases a very large amount of serotonin in your brain, there are extreme consequences to that . Like Issac Newton said, “What goes up must come down.” If your brain releases all of the serotonin it has, then your brain will be very depleted of serotonin when the drug wears off. Very low serotonin from an MDMA hangover causes severe depression which is characterized by thoughts of worthlessness, lack of motivation to do anything, exhaustion, and overall sadness. The MDMA comedown is particularly dangerous for those who are often depressed or anxious as the hangover will exacerbate the negative feelings you naturally have. Someone who has major depressive disorder experiencing an MDMA comedown is at extremely high risk for self-harm or suicide because of the severe lack of serotonin for the few days after the MDMA experience. The negative feelings can last anywhere from 1 to 6 days until the brain has replenished natural serotonin balance in the brain . What does MDMA feel like Dosing Pure MDMA How illegal is MDMA What is MDMA laced with? The effects of pure MDMA manifest as both psychedelic perceptions and stimulated sensations. Molly is known as a party and dance drug because it greatly increases feelings of love, excitement, euphoria, and eagerness. On a correct dose and in the correct setting, music sounds better, dancing is more fun, connecting with other is easier and more enjoyable, and overall happiness is increased. I will explain why these feelings occur in the pharmacology portion of this drugs analysis. Overall, to imagine the effects of MDMA just think of all the times you have felt extreme pleasure, such as sex, graduating, winning a sports championship. Take the sensation of pleasure and excitement from those events and understand that MDMA mimics those events in the brain and matches those feelings. Many MDMA explain that the euphoria from the drug is actually more strong that any other activity they have gotten pleasure from before. The extreme magnitude of pleasurable feelings that MDMA delivers is the reason for its huge potential for psychological addiction and substance use disorder. The MDMA experience is subjective, while some may enjoy the feelings, others could find it underwhelming or overstimulating and not enjoyable in either situation. MDMA is an illegal Schedule 1 drug in the United States. Schedule 1 drugs are considered to have no medical benefits and high potential for abuse. The scheduling of a drug is determined by the Drug Enforcement Administration (DEA) in America. Other Schedule 1 drugs include heroin, marijuana, and LSD. The scheduling of drugs in America is very controversial and the scheduling does not always align with the current scientific research regarding the danger and abuse potential of the substances. Crystal MDMA is easier to dose if the crystals are relatively pure. Ecstasy pills have unknown amounts of MDMA in them so dosing is difficult. It is highly recommended to purchase pure MDMA crystals and reagent drug test them to confirm it is real molly. An average dose of pure MDMA crystal is about 125 milligrams. 125 mg will affect people differently based on their body weight. There are some MDMA dosing calculators online based on body weight and height. It is critical to chemical test your MDMA to confirm you have the correct drug. Molly is a very commonly “faked” or cut with other drugs like designer drugs, bath salts (cathinones) and methamphetamine. Many drugs such as MDA, 5-APB, meth, and various cathinones: Methylone, mephedrone, and N-ethyl-pentylone. The extensive list of shows the many possible “imposter substances” than can be sold as MDMA. It is very possible that a dealer does not truly know what their “ecstasy” is made of so reagent testing is absolutely essential before ingesting any form of supposed MDMA. It is recommended to use both the Marquis and Simons reagent testing kits on MDMA. By using a very small sample of the crystal or pill, using just a drop of the reagent reacts with the chemical on the sample and changes colors based on a chemical reaction. If the crystal or pill contains MDMA then the Marquis reagent can tell you the presence of MDMA or similar drugs like MDA which is a designer drug commonly used to make fake Ecstasy. Then using the Simons reagent can differentiate the presence of MDMA and other imposter substances. It is best to use a couple reagents instead of one to double check for other reactions that can indicate other substances present in the pill. It should be noted that reagent testing CANNOT tell you the strength of the pill it only tells you the presence of chemicals in it. So if the Marquis reagent indicates MDMA in the pill it can mean there is anything between 1/10th of a dose up to 5 doses, there is no way to know without thorough laboratory testing. Just because a reagent indicates that MDMA is in the pill it does not mean it is a safe dose, so always start with a test dose and build your way up to prevent a possible overdose. How to use MDMA / ecstasy safely MDMA use comes with many risks such as overdose, strain on the body, and addiction potential. Firstly, the most common risk during MDMA use is the high likelihood of extreme overexertion. Molly causes lots of energy, desire to keep moving, and not sleeping. It is easy for those under the influence to dance too much, sleep too little, and neglect their bodies reactions. Your body may give you signs of fatigue that would be noticeable when sober but MDMA may make you unaware that your heart rate is extremely high, very dehydrated, and very hot. Heat stroke, heart attack, and lethal dehydration are greatly increased while using MDMA. Since this drug is often used at concerts, raves, or clubs the users are often moving around a lot and possibly in the sun at a festival. It is crucial to remind yourself that you may be unaware of the strain your body is going through. Just because you do not feel tired that doesn’t mean you are ok to keep dancing for hours and hours on end in the sun. MDMA makes you feel such a way that blinds you from your bodies own signs telling you to do something like sit down or drink water. It is critical to reagent test MDMA. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe Reagent testing MDMA step 1 Marquis reagent Real MDMA & MDA causes a purple color that fades to black when it comes in contact with the marquis reagent Any other color besides purple fading to black indicates the pill does not contain MDMA or MDA and may be laced with a different drug Reagent testing MDMA step 2 Simon's reagent Real MDMA causes a dark blue when it comes in contact with the Simon's reagent. MDA should have no reaction. The only purpose of Simon's reagent here is to distinguish MDMA from MDA. Step 1 and 3 must be done along with Simon's to be confident. Reagent testing MDMA step 3 Froehde reagent Both MDMA & MDA causes a dark bluish black when it comes in contact with this reagent. The only purpose of the froehde reagent here is to test for other drug MDMA is commonly laced with. Step 1 and 3 must be done along with Simon's to be confident. Final Step ALWAYS USE A FENTANYL TESTING STRIP Use a fentanyl test for every drug you intend to take. it will save your life. Mixing MDMA with other drugs & serotonin syndrome Users often dangerously mix MDMA with other drugs to enhance the trip and euphoric feelings. MDMA is sometimes mixed with the psychedelic 2C-B called “Nexus Flipping ” or MDMA and LSD called “candy flipping .” Mixing 2 or more psychedelic or stimulant drugs can be very dangerous as the effects become more unpredictable and can synergize the drug’s effects making overdose or overstimulation much more likely. One possible risk of mixing 2 psychedelics together is serotonin syndrome. Serotonin syndrome is a complication when serotonin levels in the brain are too high and the body cannot counteract it. Mixing 2 drugs that influence serotonin such as antidepressants and MDMA can cause large amounts of serotonin release and too little reuptake which overloads the serotonin receptors. Serotonin syndrome symptoms include muscle spasms, severe confusion, seizures, hyperventilation, and in very severe cases death by heart attack. Serotonin syndrome is very serious and should be considered before deciding to mix 2 or more psychedelic drugs. Anything that effects serotonin risks serotonin syndrome, everything from antidepressants, LSD, MDMA, psilocybin mushrooms, amphetamines, and opioids as well. Other than serotonin syndrome the individual effects of each additional drug can present danger. MDMA is known to increase blood pressure, heart rate, and body temperature . MDMA effects mixed with another stimulant like amphetamines (Adderall, speed, meth) which also cause increased heart rate can put excessive stress on the body and increase likelihood of heart attack, seizure, stroke, and overheating. MDMA / ecstasy is a very powerful drug and consuming other substances with it should be avoided or very cautiously dosed and thought out at the very least. Molly is a substance from the empathogen drug class There are not many empathogens used for recreational use but MDMA and its analogues are the most popular empathogens. MDMA analogues and similar drugs include MDA, MDEA, 5-APB, methylone, mephedrone, and many others.

Learn about DMT. How to use it, how to stay safe, and how it effects the brain Pharmacology DMT Q&A DMT is often called “the spirit molecule” It is thought to be the most potent psychedelic drug known to science. DMT induces full out of body experiences known as ego death where the ability to realize you are alive or have lived is lost. DMT safety and dosing DMT stands for Dimethyltryptamine and 5-MeO-DMT is 5-methoxy-dimethyltryptamine. DMT is much stronger and lasts much less time than other psychedelics like LSD or mushrooms. The dosing guidelines provided below are for smoking DMT. Disclaimer: the dosage guidelines provided are extremely rough estimates and are not concrete. Variables such as purity, person's weight, and brain chemistry differences can all affect how DMT affects you at a certain dose. Use the dosages provided as a general idea and ALWAYS START SMALL and work your way up. There are defined levels and terminology for DMT trips. The difference between 30 and 40 mg of DMT powder causes a much stronger experience and is not noticeable to the naked eye. You must use a high quality milligram scale to safely dose this drug. DMT is often sold as a crystal or powder and is often smoked. Many people choose to put DMT onto marijuana and smoke it but that is not recommended as mixing marijuana with psychedelics raises the chances of having an overwhelming trip. DMT crystals are can be completely white but impurities in powders can cause an off-white, yellow, or light brownish color which is normal. Smoked DMT powder is often described as smelling and tasting like rubber or mothballs which is very distinct from any other smell. ayahuasca Dosing Pure DMT How illegal is DMT Ayahuasca is a brewed liquid traditionally from root bark and plants that contain DMT. Ayahuasca has a long history of use by South American religious groups as a sacred ritual where ayahuasca (DMT) drinks are consumed to cause psychedelic and spiritual experiences. The word ayahuasca is the name of a vine from the Amazon that contains DMT. While there are many plants used for ayahuasca a popular source of DMT is from the root bark of the plant Mimosa Hostilis. Mimosa Hostilis root bark is boiled which extracts the DMT from it. Drinking DMT root bark tea by itself will not give psychedelic effects. DMT is not an orally active molecule which is why the powder is often smoked. To make DMT tea orally active there must be a Monoamine oxidase inhibitor (MAOI) present. The liver enzyme Monoamine Oxidase breaks the DMT molecule down into a non-psychoactive derivative before it has a chance to cause psychedelic effects. Many metabolites are produced from DMT break down but mainly DMT-N-oxide (DMT-NO), and indole-3-acetic acid (IAA) which are not hallucinogenic. To prevent DMT breakdown in the liver the monoamine oxidase (MAO) must be blocked by way of a monoamine oxidase inhibitor (MAOI). Many ayahuasca brews contain both a bark like Mimosa Hostilis and a plant containing MAOIs such as Banisteriopsis caapi (BC) and Peganum harmala (PH). Both MAOI plants contain an active monoamine oxidase inhibitor such as β-carbolines harmalol, harmine, and harmaline. By brewing a DMT-containing bark like Mimosa Hostilis and MAOI-containing plant such as Peganum harmala together the resulting brew will cause hallucinogenic DMT effects when consumed. DMT containing plants such as Mimosa hostilis root bark are usually legal to purchase and possess in the united states. Although pure DMT powder is a schedule 1 illegal drug there is a grey area in the law about the entire plant. Purchasing and possessing the plant or bark is legal while extracting and consuming DMT is illegal. DMT is an illegal Schedule 1 drug in the United States. Schedule 1 drugs are considered to have no medical benefits and high potential for abuse. The scheduling of a drug is determined by the Drug Enforcement Administration (DEA) in America. Other Schedule 1 drugs include heroin, marijuana, and ecstasy (MDMA). The scheduling of drugs in America is very controversial and the scheduling does not always align with the current scientific research regarding the danger and abuse potential of the substances. DMT containing plants such as Mimosa hostilis root bark are usually legal to purchase and possess in the united states. Although pure DMT powder is a schedule 1 illegal drug there is a grey area in the law about the entire plant. Purchasing and possessing the plant or bark is legal while extracting and consuming DMT is illegal. An effective dose of DMT is very small and extremely potent so accurate measuring is crucial. You must use a scale that measures milligrams accurately and reliably. The average dose of smoked crystal (freebase) DMT is anywhere from 20 to 40 milligrams or 0.02 to 0.04 grams. Anything above 40 milligrams has a high chance of overwhelming the average person. DMT doses are so small that you must weigh them with a precision scale to remain safe and in control of your dose. For perspective, 50 milligrams is about how much a grain of rice weighs which is very small. Warning DMT carts are easily laced with deadly drugs like fentanyl. carts are the most dangerous way to ingest DMT How Ayahuasca is made Mimosa hostilis root bark DMT containing root bark is shredded and boiled to extract the psychedelic component Banisteriopsis caapi vine A monoamine oxidase inhibitor (MAOI) containing vine or bark is boiled with the DMT containing source to make the DMT orally active so psychedelic effects to occur when the brew is consumed Final product: ayahuasca The final brew contains orally active DMT which causes intense psychedelic effects when drank.

Learn Psychedelic mushroom dose, safety tips, effects, and how they effect the brain. Psilocybin-Pilze Mushroom Q&A Psilocybin-Pilze, auch bekannt als Zauberpilze oder Shrooms, sind psychedelische Pilze, die visuelle Verzerrungen und verändertes Denken und Wahrnehmung hervorrufen, ganz ähnlich wie LSD. Psychedelische Pilze sind eine lang anhaltende halluzinogene Droge, die angebaut, getrocknet und dann durch direkten Verzehr oder durch Einlegen der Pilze in Tee, Schokolade oder Kapseln konsumiert wird. Shrooms gelten als ebenso nicht süchtig machend wie LSD und DMT. Dosen und Effekte Sind psychedelische Pilze süchtig machend? Wie illegal sind Pilze? Pilze gelten als nicht süchtig machend, ähnlich wie LSD und DMT. Es gibt zwei Arten von "Sucht", nämlich psychische Abhängigkeit und physische Abhängigkeit. Magic Pilze sind ein Rauschmittel, das PSYCHISCHE Abhängigkeit verursachen kann, aber KEINE physische Abhängigkeit. Psychische Sucht Psychische Sucht tritt auf, wenn jemand das Gefühl eines Rauschmittels wirklich genießt. Die angenehmen Gefühle veranlassen die Person, das Rauschmittel weiter zu verwenden, um das gleiche Gefühl zu wiederholen. Jemand, der es genießt, mit Pilzen zu trippen, kann weiterhin Pilze nehmen, weil er diese Gefühle genießt. Wiederholter Gebrauch von Pilzen kann als psychische Sucht betrachtet werden, wenn der Drogenkonsum exzessiv wird und negativ auf die Gesundheit, Arbeit, Schule oder das soziale Leben der Person auswirkt. Psychische Sucht ist auch bei Menschen häufig, die an Depressionen, Angstzuständen und vielen anderen psychischen oder emotionalen Problemen leiden. Der wiederholte Gebrauch eines Rauschmittels, um der Realität zu entfliehen oder vor Lebensproblemen zu fliehen, kann als psychische Abhängigkeit betrachtet werden. Physische Sucht Physische Abhängigkeit tritt auf, wenn ein Rauschmittel so oft genommen wird, dass der Körper die Anwesenheit des Rauschmittels im Körper als normal betrachtet. Der Körper glaubt, dass das Rauschmittel ständig benötigt wird, um normal zu funktionieren. Wenn der Drogenkonsum gestoppt wird, reagiert der Körper, als ob etwas Wesentliches fehlt. Die negativen Entzugserscheinungen sind die Reaktion des Körpers auf das Fehlen des Rauschmittels. Intensive Verlangen, physische Symptome wie Angstzustände, Schwitzen, Unruhe und andere Gefühle, die dem Grippe-ähnlichen Zustand ähneln, sind häufig. Jemand, der Magic Pilze sehr häufig nimmt, muss die Dosis ständig erhöhen, um den Trip so stark wie bei den ersten paar Malen zu erleben. Wenn der intensive Pilzkonsum gestoppt wird, kann es zu einem leichten Verlangen oder niedrigem Verlangen nach dem Rauschmittel kommen, aber Pilze können keine physischen Entzugserscheinungen wie Übelkeit, Schwitzen, Angstzustände, Unruhe usw. verursachen. Einsetzen – tritt innerhalb einer Stunde auf und hält für 2 Stunden nach der Einnahme an Höhepunkt (stärkste Effekte) – 3 Stunden nach der Einnahme Abklingen (Effekte nehmen langsam ab) – Stunde 4 bis 5 "Nachglow" (anhaltende positive Stimmung) – kann für 2 bis 3 Stunden nach dem Abklingen der Effekte anhalten Mikrodosierung (0,1 bis 0,25 Gramm) keine psychedelischen Effekte (visuell) und nur ein leichtes Stimmungsaufhellern tritt auf. Die Mikrodosierung beeinflusst nur das Unterbewusstsein, die Emotionen, das Denken und die Wahrnehmung. Viele glauben, dass Mikrodosierung oft die Produktivität und Kreativität steigert und möglicherweise antidepressive Effekte hat. Die Vorteile werden erforscht, aber ohne gründliche Forschung können keine endgültigen Schlussfolgerungen über Risiken und Nutzen gezogen werden. Sehr niedrige Dosis (0,5 bis 1 Gramm) leichtere Effekte (visuell) können auftreten. Farben können heller erscheinen und die Stimmung kann sich verbessern. Diese Dosis ist niedrig und es ist möglich, dass psychedelische Effekte nicht bemerkt werden, je nach Person. Es wird sehr empfohlen, bei dieser Dosis zu beginnen, wenn Sie neu bei Pilzen oder Psychedelika im Allgemeinen sind. Niedrige bis moderate Dosis (1 bis 2 Gramm) ab 1 Gramm werden die Effekte bemerkbar. Visuelle Halluzinationen wie Farben und Muster werden sichtbar und intensiver, je höher die Dosis steigt. Gedanken und Gefühle der Stimulation beginnen, sich zu intensivieren. Durchschnittliche Dosis (2,5 bis 3,5 Gramm) 3,5 Gramm gilt als die perfekte Dosis für volle Effekte, während sie noch kontrollierbar und nicht zu intensiv für die meisten Menschen ist. Bei 3,5 Gramm sind Farben und Muster sehr bemerkbar und treten auf, wenn die Augen sowohl geöffnet als auch geschlossen sind. Objekte können "atmen", was bedeutet, dass sie sich wellenförmig und biegsam in einer magischen Art und Weise bewegen. Die Lebendigkeit der Farben ist erhöht und die Farben des Regenbogens bilden komplexe Formen, wenn die Augen geschlossen sind. Intensive Gefühle der Stimulation und Wachheit. Gedanken und Wahrnehmung sind extrem verändert im Vergleich zum nüchternen Zustand. Angst und Gefühle der Überforderung sind definitiv möglich, aber diese Dosis kann keinen körperlichen Schaden verursachen und wird nicht für immer anhalten. Sehr hohe Dosis (4,5 Gramm und höher) hohe Dosis, oft als "heroische Dosis" bezeichnet - 4,5 Gramm und mehr ist sehr potent und markiert den Punkt, an dem übermäßig intensive Effekte wahrscheinlicher werden. Die Effekte von 5 Gramm können für jeden Anfänger oder sogar leicht erfahrenen Tripper zu intensiv sein. Bei dieser Dosis können die psychedelischen visuellen Effekte so intensiv werden, dass es schwierig ist, geradeaus zu sehen und Dinge in der Umgebung zu identifizieren, was sehr gefährlich sein kann. Gedankenkreise sind sehr häufig bei dieser Dosis und negative Kreise, einschließlich Schrecken, Paranoia und Abkopplung von der Realität, können überwältigend sein und zu Ausbrüchen oder irrationalen Handlungen führen. Es ist kritisch, jemanden zu haben, dem Sie vertrauen und der nüchtern bleibt, um Sie bei einer so hohen Dosis sicher zu halten. Ein genauer Gramm-Waage und ein Trip-Sitter sind sehr wichtig für jeden Pilz-Trip, insbesondere für einen stärkeren. Wie man die Dosis von Pilzen testet Es ist von entscheidender Bedeutung, die Dosis (0,1 bis 0,5 Gramm) jedes Pilz-Batchs zu testen, um ihre Stärke zu überprüfen. Es ist möglich, dass eine Pilzart 10-mal stärker ist als eine andere Art. Während 3,5 Gramm die durchschnittliche Dosis ist, wird es stark empfohlen, jede Pilzart so zu behandeln, als ob sie extrem potent ist und die Dosis langsam zu erhöhen. Die Pilz-Trip-Erfahrung ist sehr tiefgründig und intensiv, sogar bei normalen Dosen von 3,5 Gramm mit durchschnittlich potenten Pilzen. Eine normale Dosis benötigt zwischen 15 Minuten und einer Stunde, um zu wirken. Der Come-up-Prozess dauert etwa 2 Stunden an, seit der Einnahme, und die stärksten Effekte treten von etwa Stunde 3 bis Stunde 4 nach der Einnahme auf. Der Höhepunkt der Effekte dauert etwa eine Stunde an und kann starke Zeitverzerrungen verursachen, indem die Wahrnehmung von Zeit beschleunigt oder verlangsamt wird. Flüssige Farben und Objektverzerrungen können auftreten, bei denen Objekte so erscheinen, als ob sie sich wellenförmig oder "atmend" bewegen. Die Pilz-Effekte beginnen etwa eine Stunde nach dem Höhepunkt zu nachlassen und sind nach etwa 6 Stunden größtenteils verschwunden. Psychedelische Pilze sind in den Vereinigten Staaten ein illegales Rauschmittel der Klasse 1. Rauschmittel der Klasse 1 gelten als substanzien, die keine medizinischen Vorteile haben und ein hohes Potenzial für Missbrauch aufweisen. Die Einstufung eines Rauschmittels wird von der Drug Enforcement Administration (DEA) in Amerika bestimmt. Andere Rauschmittel der Klasse 1 umfassen Heroin, Marihuana, LSD und Ecstasy (MDMA). Die Einstufung von Rauschmitteln in Amerika ist sehr umstritten und die Einstufung stimmt nicht immer mit den aktuellen wissenschaftlichen Forschungsergebnissen über die Gefahr und das Missbrauchspotenzial der Substanzen überein. Pilz-Pharmakologie Wie Psychedelika das Gehirn beeinflussen Pilze sind ein monoaminerges Psychedelikum, das eine chemische Struktur sehr ähnlich dem Neurotransmitter (Gehirnchemikalie) Serotonin hat. Dieses Pilzgewächs wird "Psilocybin"-Pilz genannt, weil die Chemikalie Psilocybin in hohen Konzentrationen vorhanden ist. Pilze können nicht injiziert, geschnupft oder im Mund aufgelöst werden. Die Stiele und Hüte von Pilzen können nur gegessen werden, um wirksam zu sein, weil die metabolisierende Wirkung notwendig ist, damit das Medikament wirkt. Psilocybin, das in Pilzen vorhanden ist, muss verdaut und in die Chemikalie "Psilocin" umgewandelt werden, die tatsächlich für die psychedelischen Effekte verantwortlich ist. Psilocybin ist 4-Phosphoryloxy-Dimethyltryptamin. Wenn es eingenommen wird, entfernt die Leber die Phosphatgruppe und das Molekül Psilocin wird erstellt (4-Hydroxy-Dimethyltryptamin). Psilocin durchquert die Blut-Hirn-Schranke und bindet an verschiedene Serotonin-Rezeptoren, hauptsächlich den 5HT2A-Rezeptor. Psychedelische Pilze funktionieren sehr ähnlich wie LSD im Gehirn, aber Pilze haben eine kürzere Dauer im Vergleich zu LSD, weil Psilocin-Moleküle weniger Zeit damit verbringen, die Serotonin-Rezeptoren zu aktivieren, und schneller abgebaut werden als LSD. Der auffälligste Unterschied zwischen LSD und Psilocybin-Pilzen ist die Länge des Trips und die subjektiven visuellen Verzerrungen. LSD-Visuelle Effekte werden oft als geometrisch und regenbogenfarben beschrieben, während Pilz-Visuelle Effekte oft als flüssiger und wellenförmiger beschrieben werden. LSD ist mehr gerade Linien und geometrische Formen, während Pilze mehr wellenförmige Linien und schmelzende/fließende Farben sind. Aber der Wirkungsmechanismus im Gehirn zwischen LSD und Pilzen ist sehr ähnlich, pharmakologisch gesehen. Chemische Reaktion in der Leber Die Dihydrogenphosphat-Gruppe wird entfernt und Psilocin wird gebildet. Psilocin ist der wirksame Bestandteil, der die Serotonin-Rezeptoren im Gehirn aktiviert.

Learn LSD dose, effects, safety tips, and how acid works in the brain. LSD LSD, also known as Acid & Lucy, is a very potent psychedelic drug that causes visual hallucinations and alters perception and mood. The acronym LSD stands for Lysergic acid diethylamide. LSD effects are similar to psilocybin mushrooms (magic mushrooms), as they both mimic the brain chemical serotonin. the duration of the trip lasts approximately 6 to 10 hours with the strongest effects occurring at 3 hours after ingestion. Pharmacology LSD tab dosing How to dose correctly What does LSD feel like? To safely ingest LSD it is crucial to understand that it is very potent even in low doses. A typical dose of LSD is 100 micrograms which is equivalent to 0.1 milligrams or roughly the size of a grain of sand. One tab can contain anywhere from 1 microgram to 500 micrograms. It is difficult to determine the correct dose of LSD because a couple grains of sand worth of LSD can turn a normal dose into an extremely strong one. Doses are sold in various forms including, blotter paper, gelatin tabs, or crystal LSD dissolved in alcohol known as a “vial.” It is not possible to precisely know how many micrograms are on a tab without lab testing so it is critical to take a test dose. Microdosing 1/20th to 1/10th of a tab no psychedelic (visual) effects but minor mood lifting may occur. The microdose level should only influence subconscious emotion, thinking, and perception. Many believe microdosing increases both productivity and creativity and has anti-depressent effects. The benefits are being researched but no definitive conclusions about risk and reward can be given without thorough research. Very low dose (1/10th to 1/5th of a tab Minor psychedelic (visual) effects may or may not occur. Colors may seem brighter and surfaces may have moving patterns covering them. Mood should be noticeably altered with increased deep thought and noticing details, colors, and surroundings like nature may be much different than sober perceptions. Low to moderate dose (1/4 to 1/5 of a tab) Effects will become very noticeable above a quarter tab. visual hallucinations like colors and patters will become apparent and increase in intensity as the dose increases after .25 tabs. Wonder filled thoughts and feelings of stimulation begin to intensify at this dose. Mood can increase with feelings of exitement and slight euphoria. Even a low dose can cause anxiety and sometimes fear if your mindset and location are not correct. Tripping in a very public place like a concert or crowded beach are more likely to cause anxiety compared to a calm house or soothing nature. normal dose (full psychedelic trip) 1 full tab 1 tab is designed to be the perfect dose for full psychedelic effects while usually remaining controllable and not too intense for. at 1 full tab the colors and patterns are very apparent and occur when eyes are both open and closed. Objects often “breath” which means swaying and bending in a magical type way. You may notice the floor, walls, trees, hands, and surfaces sway and have patterns overlayed on them. Vibrancy of colors is heightened and closed eye visuals contain all colors of the rainbow that create complex shapes and infinite kaleidoscopic patterns. Intense feelings of stimulation and alertness. Even though 1 tab is an average dose for a full trip there is still a chance that paranoia or anxiety can occur. The best way to prevent them is to take LSD with people you trust in a place that makes you calm / comfortable Very heavy dose (greater than 1 full tab) heavy doses above 1 full tab are very potent and marks the point where bad trips become more likely. The effects of 1.5 to 3 tabs may be much too intense for any beginner or even experienced people. At this dose the psychedelic visuals may distort and fill vision so intensely that it is difficult to see straight and identify things around you which is very dangerous. Thought loops are very common at these doses and negative loops including terror, paranoia, and detachment from reality may be overwhelming and cause outbursts or extreme confusion. It is critical to have someone you trust who remains sober to keep you safe on a dose that large. Ego death is possible when many tabs are taken at once. Ego death is when the trip is so strong you forget that you are alive and is similar to being in a trance. Time and reality and shattered and your actions and behavior may be out of your control. It is extremely risky to experience ego death alone, with strangers, or anywhere in public. To test the strength of a tab, it is advised to start by ingesting 10% of a tab to gauge the strength. 10% of a normal 100 microgram tab should not cause any visual distortions whatsoever. You may experience slight mood changes but such a low dose should cause very minimal noticeable effects. If visual effects are noticeable with 10% of a tab then the tab is much stronger than a standard dose. Once a low dose is tested you can help prevent taking too much in the future. If you are confident that 10% of a tab is not strong then slowly start increasing amount of dose up to a full tab. LSD can be absorbed in the mouth or digested in the stomach. The most effective method of ingestion involves placing the tab underneath the tongue then swallowing the paper 15 minutes later. Alternatively, the tab can be swallowed immediately but the psychedelic effects may be delayed a bit longer than the under the tongue method. After ingesting the tab, the effects should begin within 45 minutes. If there are no effects at all within 1.5 hours the tab is either very weak or did not contain LSD at all. DO NOT take another tab unless at least 2.5 hours have gone by with zero effects. You do not want to take another dose before the last one has gotten the full amount of time to onset. LSD Q&A Onset – occurs within an hour Intensity increase – hour 1 to 3 Peak - (strongest effects) – 3 hours after ingestion Come down - (effects slowly waring off) hour 4 to 8 "afterglow” - (lingering positive mood) – can last for 2 to 8 hours after effects have worn off How to see if your LSD is real It is critical to reagent test LSD. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe Reagent testing LSD step 1 Ehrlich reagent Real LSD causes a purple color when it comes in contact with the Ehrlich reagent Any other color besides purple indicates the tab does not contain LSD and may be laced with a different drug It is critical to reagent test your LSD to confirm you have the correct drug. Reagent testing LSD is extremely recommended because it can save your life. The “Ehrlich” reagent test is the preferred test for LSD. The Ehrlich reagent kit will reliably test blotter tabs of LSD. The Ehrlich reagent works by placing one drop of the reagent on about 1/20th of a blotter tab. The reagent reacts with the chemical on the tab and changes colors based on the chemical reaction. If the LSD is real then the Ehrlich reagent will yield a purple color within 5 seconds to 5 minutes. If there is no color or anything different than purple you cannot be certain your tab contains LSD and you should throw the tabs away. Reagent testing LSD step 2 Hoffman reagent Real LSD causes a blue color when it comes in contact with the Hoffman reagent NBOMe drugs are an LSD imposter substance that can kill you. Make sure the color is not yellow or amber colored. Those colors indicate a drug different than LSD and may be NBOMe drugs. (See 25D and 25B NBOMe in the image to the right). You must use the Hoffman reagent as well to test tabs. Hoffman reagent can detect the difference between real LSD and different variants of NBOME. The Hoffman reagent yields a blue color when it touches real LSD and different types of yellow or pink for other substances like 25i-nbome, 2c-I, and 25B-NBOME. There are similarities and very important differences between LSD and NBOME. LSD dose ranges from 40 micrograms (low) to 250 (high) with the average being 100 to 150 micrograms. Whereas NBOME doses are mild at 250 to 450 micrograms high doses are around 450 to 800 micrograms. The dosages between LSD and NBOME seem different in numbers but the difference of 200 micrograms to 600 is extremely small to the naked eye. Since it is nearly impossible to visually distinguish how much of a drug is on blotter paper or in a vial or gelatin tabs it is best to test the substance with an Ehrlich reagent kit. LSD by itself can not kill you by overdose but NBOME can kill you very easily. The worst that can happen in a high LSD dose is terror, anxiety, and confusion. But you will live and not experience noticeable brain damage even in extremely high doses. On the other hand, NBOME compounds can directly kill you LSD in any form like blotter paper, gelatin tabs, or liquid in a vial is tasteless and odorless. An LSD dose cannot be visually measured because 100 micrograms is microscopic. It is essential to be aware that street dealers may sell dangerous counterfeit substances presented as LSD. For instance, the psychedelic compound 25I-NBOMe is sometimes passed off as acid. However, NBOMe compounds are much more harmful than LSD, only a few grains of salt worth of NBOME compounds can lead to severe health complications, including heart failure, seizures, and death. LSD doses typically range from 40 micrograms (low) to 250 micrograms (high), with the average dose falling between 100 to 150 micrograms. In contrast, NBOMe doses are considered mild at 250 to 450 micrograms, with high doses reaching around 450 to 800 micrograms. While the microgram gap may seem large, in reality, a difference of 300 micrograms is extremely hard to visually notice while being much more powerful. Given that visually determining the quantity of a substance on blotter paper, in a vial, or gelatin tabs is virtually impossible, it is highly recommended to test the substance using an Ehrlich reagent kit. NBOMe compounds have the potential to cause lethal consequences. The lethal dose of NBOMe can be as little as 2 milligrams (2000 micrograms), which is a minuscule amount. What is LSD tolerance? LSD often carries misconceptions and negative stigma in the public eye. While all psychoactive substances carry risks, the level and nature of the risk vary between different drugs. LSD is widely recognized as having a very low potential for addiction. The low addiction risk is due to the unique tolerance built for LSD when used consistently. When is LSD used more than once a week tolerance builds up quickly, requiring higher doses to achieve the same effects. For example, if someone takes a 100 microgram tab of LSD every day for a week, by the seventh day, that same 100 microgram tab would have significantly diminished psychedelic effects, perhaps feeling like only 1.5 micrograms which has zero psychedelic effects. The drastic drop in effect makes LSD nearly impossible to become addicted to because you have to increase the dose to absurd levels. After a week of everyday use, someone would have to consume 128 tabs to feel average psychedelic effects. The number of LSD needed to be consumed is doubled each consecutive day it is used which makes the likelihood of someone becoming addicted to LSD extremely low. Similarly, there have been zero reliably recorded cases of LSD overdose caused solely by LSD in those without prior medical conditions or mixing other substances with LSD. 100 LSD gel tabs Gel tabs come in many different colors and shapes Color or shape do not indicate strength or purity 100 LSD blotter tabs Blotter tabs can have infinite amount of designs. The design does not indicate strength or purity

Learn how amphetamines effect the brain from a simplified neuroscience perspective Meth and adderall pharmacology It might be suprising to some but meth and adderall work the EXACT SAME WAY in the brain everything written below applies to both meth and adderall equally main page American society often associates methamphetamine with addiction, death, overdose, and crazy people. Adderall is viewed as a medicine good for studying and productivity at work. Pharmacology research and chemical analysis shows that methamphetamine and Adderall are the EXACT SAME DRUG when it comes to addiction potential, psychoactive effects, as well as mental damage. All scientific literature you can find online will tell you the chemical structures are 99% similar and the 1% difference goes away one once the drug is ingested in any form. The images below displays the similarities. Amphetamine base chemical name is alpha-methylphenethylamine Crystal Methamphetamine is a hydrochloride salt Adderall is a mixture of levoamphetamine and dextroamphetamine Amphetamines bind to presynaptic membrane of dopaminergic neurons and release massive amounts of dopamine especially in the striatum. Then amphetamine molecules bind to dopamine reuptake transporters which prevents dopamine from leaving synaptic gap and reversing dopamine transporters which causes free dopamine to be transported out of the terminal. High doses of amphetamines even cause monoamine oxidase inhibition which prevents dopamine, epinephrine, norepinephrine, and serotonin breakdown. Inhibiting monoamine oxidase increases all monoamine prevalence and receptor interactions. Chemical comparison Amphetamine (Adderall) only has 1 more hydrogen and 1 less methyl group (CH3) than meth. Next page Our Clients