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  • amphetamine safety practices | DrugSpeak

    Learn how to safely take amphetamines like adderall, ritalin, and meth. How to safely use drugs for productivity, studying, and recreation. Click Here How to remain safe using street Adderall The largest concern with Adderall pills is the risk that they can be counterfeit, laced with meth or other drugs, and if they are the correct drug the amount of milligrams may be different than the pill’s label. These risks apply to Adderall pills not from a pharmacy / prescription. The rule of thumb is if you did not personally pick them up from the pharmacy with your prescription then you MUST assume they are counterfeit. Never believe a dealer that says he got them from a pharmacy even if they show you a prescription. Any pill from anywhere other than a pharmacy is a “street” counterfeit pill. Dealers and producers can buy amphetamine powder on the darknet and a pill press machine from amazon and make a pill that looks identical to a real pharmaceutical grade pill. DO not try to visually distinguish real from fake pills. Additionally, if you test your Adderall and it tests positive for the correct drug, you can never know how much of the drug is in the pill. Never blindly believe the pills label If its stamped “30” or “15” indicating the amount of milligrams. Counterfeit dealers often press an incorrect amount of the amphetamine powder into the pill. There is not a test to determine how strong the pill is so after reagent testing the pill, it is recommended to swallow 10% of the pill to gauge how strong it is. Counterfeit Adderall often contain no Adderall at all and are made with powdered methamphetamine mixed into colored pill binder and pressed into the shape and color of real pills. Methamphetamine is cheaper and easier to produce than amphetamine (Adderall) powder so dealers can make more money selling meth and calling it Adderall. If you get Adderall pills from anywhere besides a pharmacy with your prescription you MUST reagent test the drug to make sure your pills are not methamphetamine. Many websites sell the test kits can decipher Adderall from meth It is critical to reagent test Adderall / meth. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe How to reagent test Meth and adderall Step 1 You need to buy the marquis OR Liebermann reagent. Either of these tests will turn orange when EITHER meth or Adderall is detected. The marquis or Liebermann test will tell you if you have a type of amphetamine and not a completely different drug like heroin or MDMA. Only Meth and Adderall turn orange when using this test. Step 2 Then you must buy the Simon’s reagent to see if you have meth OR Adderall. When placing a drop of the simons reagent on a small portion of the pill, the reagent will turn blue if the pill is made of meth and have no reaction if the pill is Adderall. step 3 You must use a fentanyl contamination test to make sure the meth or adderall is not laced with fentanyl. As little as 2 grains of sand worth of fentanyl can be deadly. This step is as important as the previous 2 steps. Information to note YOU MUST UNDERSTAND that both marquis OR lieberman in addition to simons need to be used. Using only 1 reagent and not the other will not give you enough information to confidently say the pill is meth or Adderall. After both steps of reagent testing it is likely that the results from the reagents determined the correct drug.

  • All about magic mushrooms | DrugSpeak

    Learn Psychedelic mushroom dose, safety tips, effects, and how they effect the brain. Psilocybin-Pilze Mushroom Q&A Psilocybin-Pilze, auch bekannt als Zauberpilze oder Shrooms, sind psychedelische Pilze, die visuelle Verzerrungen und verändertes Denken und Wahrnehmung hervorrufen, ganz ähnlich wie LSD. Psychedelische Pilze sind eine lang anhaltende halluzinogene Droge, die angebaut, getrocknet und dann durch direkten Verzehr oder durch Einlegen der Pilze in Tee, Schokolade oder Kapseln konsumiert wird. Shrooms gelten als ebenso nicht süchtig machend wie LSD und DMT. Sind psychedelische Pilze süchtig machend? Wie illegal sind Pilze? Dosen und Effekte Pilze gelten als nicht süchtig machend, ähnlich wie LSD und DMT. Es gibt zwei Arten von "Sucht", nämlich psychische Abhängigkeit und physische Abhängigkeit. Magic Pilze sind ein Rauschmittel, das PSYCHISCHE Abhängigkeit verursachen kann, aber KEINE physische Abhängigkeit. Psychische Sucht Psychische Sucht tritt auf, wenn jemand das Gefühl eines Rauschmittels wirklich genießt. Die angenehmen Gefühle veranlassen die Person, das Rauschmittel weiter zu verwenden, um das gleiche Gefühl zu wiederholen. Jemand, der es genießt, mit Pilzen zu trippen, kann weiterhin Pilze nehmen, weil er diese Gefühle genießt. Wiederholter Gebrauch von Pilzen kann als psychische Sucht betrachtet werden, wenn der Drogenkonsum exzessiv wird und negativ auf die Gesundheit, Arbeit, Schule oder das soziale Leben der Person auswirkt. Psychische Sucht ist auch bei Menschen häufig, die an Depressionen, Angstzuständen und vielen anderen psychischen oder emotionalen Problemen leiden. Der wiederholte Gebrauch eines Rauschmittels, um der Realität zu entfliehen oder vor Lebensproblemen zu fliehen, kann als psychische Abhängigkeit betrachtet werden. Physische Sucht Physische Abhängigkeit tritt auf, wenn ein Rauschmittel so oft genommen wird, dass der Körper die Anwesenheit des Rauschmittels im Körper als normal betrachtet. Der Körper glaubt, dass das Rauschmittel ständig benötigt wird, um normal zu funktionieren. Wenn der Drogenkonsum gestoppt wird, reagiert der Körper, als ob etwas Wesentliches fehlt. Die negativen Entzugserscheinungen sind die Reaktion des Körpers auf das Fehlen des Rauschmittels. Intensive Verlangen, physische Symptome wie Angstzustände, Schwitzen, Unruhe und andere Gefühle, die dem Grippe-ähnlichen Zustand ähneln, sind häufig. Jemand, der Magic Pilze sehr häufig nimmt, muss die Dosis ständig erhöhen, um den Trip so stark wie bei den ersten paar Malen zu erleben. Wenn der intensive Pilzkonsum gestoppt wird, kann es zu einem leichten Verlangen oder niedrigem Verlangen nach dem Rauschmittel kommen, aber Pilze können keine physischen Entzugserscheinungen wie Übelkeit, Schwitzen, Angstzustände, Unruhe usw. verursachen. Einsetzen – tritt innerhalb einer Stunde auf und hält für 2 Stunden nach der Einnahme an Höhepunkt (stärkste Effekte) – 3 Stunden nach der Einnahme Abklingen (Effekte nehmen langsam ab) – Stunde 4 bis 5 "Nachglow" (anhaltende positive Stimmung) – kann für 2 bis 3 Stunden nach dem Abklingen der Effekte anhalten Mikrodosierung (0,1 bis 0,25 Gramm) keine psychedelischen Effekte (visuell) und nur ein leichtes Stimmungsaufhellern tritt auf. Die Mikrodosierung beeinflusst nur das Unterbewusstsein, die Emotionen, das Denken und die Wahrnehmung. Viele glauben, dass Mikrodosierung oft die Produktivität und Kreativität steigert und möglicherweise antidepressive Effekte hat. Die Vorteile werden erforscht, aber ohne gründliche Forschung können keine endgültigen Schlussfolgerungen über Risiken und Nutzen gezogen werden. Sehr niedrige Dosis (0,5 bis 1 Gramm) leichtere Effekte (visuell) können auftreten. Farben können heller erscheinen und die Stimmung kann sich verbessern. Diese Dosis ist niedrig und es ist möglich, dass psychedelische Effekte nicht bemerkt werden, je nach Person. Es wird sehr empfohlen, bei dieser Dosis zu beginnen, wenn Sie neu bei Pilzen oder Psychedelika im Allgemeinen sind. Niedrige bis moderate Dosis (1 bis 2 Gramm) ab 1 Gramm werden die Effekte bemerkbar. Visuelle Halluzinationen wie Farben und Muster werden sichtbar und intensiver, je höher die Dosis steigt. Gedanken und Gefühle der Stimulation beginnen, sich zu intensivieren. Durchschnittliche Dosis (2,5 bis 3,5 Gramm) 3,5 Gramm gilt als die perfekte Dosis für volle Effekte, während sie noch kontrollierbar und nicht zu intensiv für die meisten Menschen ist. Bei 3,5 Gramm sind Farben und Muster sehr bemerkbar und treten auf, wenn die Augen sowohl geöffnet als auch geschlossen sind. Objekte können "atmen", was bedeutet, dass sie sich wellenförmig und biegsam in einer magischen Art und Weise bewegen. Die Lebendigkeit der Farben ist erhöht und die Farben des Regenbogens bilden komplexe Formen, wenn die Augen geschlossen sind. Intensive Gefühle der Stimulation und Wachheit. Gedanken und Wahrnehmung sind extrem verändert im Vergleich zum nüchternen Zustand. Angst und Gefühle der Überforderung sind definitiv möglich, aber diese Dosis kann keinen körperlichen Schaden verursachen und wird nicht für immer anhalten. Sehr hohe Dosis (4,5 Gramm und höher) hohe Dosis, oft als "heroische Dosis" bezeichnet - 4,5 Gramm und mehr ist sehr potent und markiert den Punkt, an dem übermäßig intensive Effekte wahrscheinlicher werden. Die Effekte von 5 Gramm können für jeden Anfänger oder sogar leicht erfahrenen Tripper zu intensiv sein. Bei dieser Dosis können die psychedelischen visuellen Effekte so intensiv werden, dass es schwierig ist, geradeaus zu sehen und Dinge in der Umgebung zu identifizieren, was sehr gefährlich sein kann. Gedankenkreise sind sehr häufig bei dieser Dosis und negative Kreise, einschließlich Schrecken, Paranoia und Abkopplung von der Realität, können überwältigend sein und zu Ausbrüchen oder irrationalen Handlungen führen. Es ist kritisch, jemanden zu haben, dem Sie vertrauen und der nüchtern bleibt, um Sie bei einer so hohen Dosis sicher zu halten. Ein genauer Gramm-Waage und ein Trip-Sitter sind sehr wichtig für jeden Pilz-Trip, insbesondere für einen stärkeren. Wie man die Dosis von Pilzen testet Es ist von entscheidender Bedeutung, die Dosis (0,1 bis 0,5 Gramm) jedes Pilz-Batchs zu testen, um ihre Stärke zu überprüfen. Es ist möglich, dass eine Pilzart 10-mal stärker ist als eine andere Art. Während 3,5 Gramm die durchschnittliche Dosis ist, wird es stark empfohlen, jede Pilzart so zu behandeln, als ob sie extrem potent ist und die Dosis langsam zu erhöhen. Die Pilz-Trip-Erfahrung ist sehr tiefgründig und intensiv, sogar bei normalen Dosen von 3,5 Gramm mit durchschnittlich potenten Pilzen. Eine normale Dosis benötigt zwischen 15 Minuten und einer Stunde, um zu wirken. Der Come-up-Prozess dauert etwa 2 Stunden an, seit der Einnahme, und die stärksten Effekte treten von etwa Stunde 3 bis Stunde 4 nach der Einnahme auf. Der Höhepunkt der Effekte dauert etwa eine Stunde an und kann starke Zeitverzerrungen verursachen, indem die Wahrnehmung von Zeit beschleunigt oder verlangsamt wird. Flüssige Farben und Objektverzerrungen können auftreten, bei denen Objekte so erscheinen, als ob sie sich wellenförmig oder "atmend" bewegen. Die Pilz-Effekte beginnen etwa eine Stunde nach dem Höhepunkt zu nachlassen und sind nach etwa 6 Stunden größtenteils verschwunden. Psychedelische Pilze sind in den Vereinigten Staaten ein illegales Rauschmittel der Klasse 1. Rauschmittel der Klasse 1 gelten als substanzien, die keine medizinischen Vorteile haben und ein hohes Potenzial für Missbrauch aufweisen. Die Einstufung eines Rauschmittels wird von der Drug Enforcement Administration (DEA) in Amerika bestimmt. Andere Rauschmittel der Klasse 1 umfassen Heroin, Marihuana, LSD und Ecstasy (MDMA). Die Einstufung von Rauschmitteln in Amerika ist sehr umstritten und die Einstufung stimmt nicht immer mit den aktuellen wissenschaftlichen Forschungsergebnissen über die Gefahr und das Missbrauchspotenzial der Substanzen überein. Pilz-Pharmakologie Wie Psychedelika das Gehirn beeinflussen Pilze sind ein monoaminerges Psychedelikum, das eine chemische Struktur sehr ähnlich dem Neurotransmitter (Gehirnchemikalie) Serotonin hat. Dieses Pilzgewächs wird "Psilocybin"-Pilz genannt, weil die Chemikalie Psilocybin in hohen Konzentrationen vorhanden ist. Pilze können nicht injiziert, geschnupft oder im Mund aufgelöst werden. Die Stiele und Hüte von Pilzen können nur gegessen werden, um wirksam zu sein, weil die metabolisierende Wirkung notwendig ist, damit das Medikament wirkt. Psilocybin, das in Pilzen vorhanden ist, muss verdaut und in die Chemikalie "Psilocin" umgewandelt werden, die tatsächlich für die psychedelischen Effekte verantwortlich ist. Psilocybin ist 4-Phosphoryloxy-Dimethyltryptamin. Wenn es eingenommen wird, entfernt die Leber die Phosphatgruppe und das Molekül Psilocin wird erstellt (4-Hydroxy-Dimethyltryptamin). Psilocin durchquert die Blut-Hirn-Schranke und bindet an verschiedene Serotonin-Rezeptoren, hauptsächlich den 5HT2A-Rezeptor. Psychedelische Pilze funktionieren sehr ähnlich wie LSD im Gehirn, aber Pilze haben eine kürzere Dauer im Vergleich zu LSD, weil Psilocin-Moleküle weniger Zeit damit verbringen, die Serotonin-Rezeptoren zu aktivieren, und schneller abgebaut werden als LSD. Der auffälligste Unterschied zwischen LSD und Psilocybin-Pilzen ist die Länge des Trips und die subjektiven visuellen Verzerrungen. LSD-Visuelle Effekte werden oft als geometrisch und regenbogenfarben beschrieben, während Pilz-Visuelle Effekte oft als flüssiger und wellenförmiger beschrieben werden. LSD ist mehr gerade Linien und geometrische Formen, während Pilze mehr wellenförmige Linien und schmelzende/fließende Farben sind. Aber der Wirkungsmechanismus im Gehirn zwischen LSD und Pilzen ist sehr ähnlich, pharmakologisch gesehen. Chemische Reaktion in der Leber Die Dihydrogenphosphat-Gruppe wird entfernt und Psilocin wird gebildet. Psilocin ist der wirksame Bestandteil, der die Serotonin-Rezeptoren im Gehirn aktiviert.

  • How to use adderall and meth safely | DrugSpeak

    Learn about Amphetamines, the dose, purity, effects, and how they work in the brain How to safely use meth and adderall (amphetamines) Meth & adderall Q&A Drugs list Amphetamine pharmacology Amphetamines are a group of stimulant drugs including Meth and Adderall. There are thousands of drugs in the amphetamine class but these 2 are the most prevalent in society. Methamphetamine and amphetamine salt (Adderall) yield extremely similar effects and carry similar risks when consumed in recreational doses. Note that any information written about ADDERALL refers to those who abuse and get high on it. Prescribed amounts for those who need the drug are not included in this article. People with ADHD taking prescribed 5mg to 20mg of Adderall are not the same as an average person snorting (sniffing) many crushed up pills to get high. Methamphetamine is also known as meth, crank, ice, crystal. Adderall is sometimes called a smart drug or study drug. Methamphetamine is illegal in all circumstances whereas Adderall can be legally prescribed for the treatment of disorders like attention deficit hyperactivity disorder (ADHD). Both drugs are central nervous stimulants or “uppers” that induce euphoria, explosive amount of energy, increase enthusiasm, ramp up heart rate, and constrict pupils / circulation. High doses of these drugs lessen the desire for eating or sleeping which has many mental and bodily consequences. The Amphetamine class of drugs used recreationally cause the user to feel stronger, more confident, smarter, and more aware then they really are. how illegal is meth / adderall meth & adderall myths The general population views meth as a hard drug that is highly addictive and ruins the life of everyone who uses it. Someone imagining a meth addict visualizes a bone skinny, raggedy, toothless, dirty homeless person. Meanwhile, when someone visualizes an Adderall user they often visualize a businessman taking drugs to manage their busy work or busy family schedule. Put simply, meth is viewed as a dangerous drug that ruins lives and Adderall as a drug used for studying and productivity for normal people. The truth, according to pharmacology, is that pure meth and Adderall are just as addictive and relatively the same danger level to consume when taken at the same dose. Both meth and Adderall equally cause sleep deprivation, weight loss, dopamine deficiency, and brain alterations. Both chemicals function the same way in the brain and carry extremely similar overdose potential. Society is mislead because meth is illegal and Adderall is a “medicine” so it is reasonable to believe that a medicine is good for you and illegal drugs are dangerous. Sadly, this is not the case. Adderall (dextro and levoamphetamine) is not a better or worse choice to make legal than using medical grade methamphetamine. The one and only reason Adderall may be considered a better option to use recreationally is because pills from a pharmacy are not likely to be laced, have impurities, and have accurate dosing. Theoretically, if you have 2 pills, one contains meth and the other contains Adderall amphetamines. Assume both are medical grade and contain no harmful additives. It would be impossible to tell which pill contains what based solely off of the effects of the drug. The only way to tell is if you test the pill with a reagent testing kit. Overall, it is highly recommended to learn about drugs on your own and not believe that legal medicines are always good and illegal drugs will always kill you. Adderall and meth are effectively the same drug with totally different public perceptions. Methamphetamine and Adderall are both Schedule 2 drugs in the United States. Schedule 2 drugs are considered to have high potential for abuse potentially leading to severe psychological or physical dependence. The scheduling of a drug is determined by the Drug Enforcement Administration (DEA) in America. Other Schedule 2 drugs include cocaine, Ritalin, oxycodone, and fentanyl. The scheduling of drugs in America is very controversial and the ranking does not always align with the current scientific research regarding the danger and abuse potential of the substances. Adderall dosing Instant release Tablets made of pressed powder effects last 4 to 6 hours usually lower dosages (5mg to 15mg) but sometimes higher dosages (30mg) Extended release capsules capsule full of amphetamine beads effects typically last 8 to 12 hours, possibly longer Higher dosages (20mg to 30mg) Adderall is available as either colored, stamped pills or orange capsules with beads. Pills provide immediate effects within an hour, while capsules offer extended release over 6urs. Some abuse Adderall by crushing snorting it, seeking a quicker rush of euphoria, which is dangerous. Snorting can harm the nose and respiratory system, as the fillers are not meant for inhalation, and it increases the drug's addictive potential due to the rapid onset of effects. Meth dosing Methamphetamine is often found in powder or crystalized form. Powder meth is often snorted, injected, swallowed in capsules. Whereas crystal meth is not snorted because it severely cuts and tears the inside of the nose. Crystal can be smoked, melted then injected, or swallowed. Due to meth being illegal and not created by a regulated company the ingredients in meth are unknown. It is recommended to swallow meth opposed to snorting, smoking, and definitely avoid injecting. Making meth includes using extremely toxic chemicals like strong acids, phosphorous and many dangerous chemicals that can damage your nose, lungs, and veins. It is extremely recommended to never do meth in any form but if you do meth it Is extremely recommended that swallowing an ACCURATELY WEIGHED small dose is the best way to avoid excess damage to internal organs. Administering meth in other ways than swallowing can lead to damage to nasal cavities, lungs, teeth, throat, and veins. The phrase “meth mouth” exists because people who smoke meth for a long time have severe tooth and gum damage. The actual methamphetamine drug itself does not cause mouth damage. It is the toxic additives that are leftover from creating the drug. How to remain safe using street Adderall Street Adderall are very commonly counterfeited, laced with meth or other drugs, and can contain the wrong dose. These risks apply to Adderall pills not from a pharmacy / prescription. The rule of thumb is if you did not personally pick them up from the pharmacy with your prescription then you MUST assume they are counterfeit. Never believe a dealer that say they got them from a pharmacy even if they show you a prescription. Always assume a dealers drugs will be laced . Dealers and producers can buy amphetamine powder and a pill press machine from amazon to make pills that looks identical to a real pharmaceutical grade pill. Do not try to visually distinguish real from fake pills. Additionally, if you test your Adderall and it tests positive for the correct drug, you can never know how much of the drug is in the pill. Never blindly believe the pills label If its stamped “30” or “15” indicating the amount of milligrams. Counterfeit dealers often press an incorrect amount of the amphetamine powder into the pill. There is not a test to determine how strong the pill is so after reagent testing the pill , it is recommended to swallow 10% of the pill to gauge how strong it is. Counterfeit Adderall often contain no Adderall at all. Many pills are made with powdered methamphetamine mixed with colored pill binder and pressed into the shape and color of real pills. Dealers can make more money selling meth and calling it Adderall. If you get Adderall pills from anywhere besides a pharmacy with your prescription you MUST reagent test the drug to make sure your pills are not methamphetamine. Many websites sell the test kits can decipher Adderall from meth It is critical to reagent test meth / Adderall. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe How to see if your Adderall is real Step 1 Buy the marquis OR Liebermann reagent. Either of these tests will turn orange when EITHER meth or Adderall is detected. The marquis / Liebermann test will tell you if you have a type of amphetamine and not a completely different drug like heroin or MDMA. Only Meth and Adderall turn orange when using this test. Step 2 Buy the Simon’s reagent to see if you have meth OR Adderall. When placing a drop of the simons reagent on a small portion of the pill, the reagent will turn blue if the pill is made of meth and have no reaction if the pill is Adderall. step 3 You must use a fentanyl contamination test. As little as 2 grains of sand worth of fentanyl can be deadly. This step is as important as the previous 2 steps. Information to note YOU MUST UNDERSTAND that both marquis OR lieberman in addition to simons need to be used. Using only 1 reagent and not the other will not give you enough information to confidently say the pill is meth or Adderall. After both steps of reagent testing it is likely that the results from the reagents determined the correct drug.

  • Drug reagent blog | DrugSpeak

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  • Ayahuasca | Drug Speak

    Learn all about the psychedelic drug ayahuasca containing DMT. How to use it, how to stay safe, and how it works in the brain and body. Ayahuasca DMT home page Ayahuasca is a brewed liquid traditionally from root bark and plants that contain DMT. Ayahuasca has a long history of use by South American religious groups as a sacred ritual where ayahuasca (DMT) drinks are consumed to cause psychedelic and spiritual experiences. The word ayahuasca is the name of a vine from the Amazon that contains DMT. While there are many plants used for ayahuasca a popular source of DMT is from the root bark of the plant Mimosa Hostilis. Mimosa Hostilis root bark is boiled which extracts the DMT from it. Drinking DMT root bark tea by itself will not give psychedelic effects. DMT is not an orally active molecule which is why the powder is often smoked. To make DMT tea orally active there must be a Monoamine oxidase inhibitor (MAOI) present. The liver enzyme Monoamine Oxidase breaks the DMT molecule down into a non-psychoactive derivative before it has a chance to cause psychedelic effects. Many metabolites are produced from DMT break down but mainly DMT-N-oxide (DMT-NO), and indole-3-acetic acid (IAA) which are not hallucinogenic. To prevent DMT breakdown in the liver the monoamine oxidase (MAO) must be blocked by way of a monoamine oxidase inhibitor (MAOI). Many ayahuasca brews contain both a bark like Mimosa Hostilis and a plant containing MAOIs such as Banisteriopsis caapi (BC) and Peganum harmala (PH). Both MAOI plants contain an active monoamine oxidase inhibitor such as β-carbolines harmalol, harmine, and harmaline. By brewing a DMT-containing bark like Mimosa Hostilis and MAOI-containing plant such as Peganum harmala together the resulting brew will cause hallucinogenic DMT effects when consumed. DMT containing plants such as Mimosa hostilis root bark are usually legal to purchase and possess in the united states. Although pure DMT powder is a schedule 1 illegal drug there is a grey area in the law about the entire plant. Purchasing and possessing the plant or bark is legal while extracting and consuming DMT is illegal. Mimosa hostilis root bark (contains DMT) Banisteriopsis caapi vine (contains MAOI inhibitor) Finished product: ayahuasca brew (contains DMT and MOAI inhibitor)

  • How MDMA / ecstasy effects the brain | DrugSpeak

    Learn how MDMA / ecstasy effect the brain from a simplified neuroscience perspective. MDMA Pharmacology MDMA Home page MDMA standing for Methylene-dioxy-methyl-amphetamine acts both as a psychedelic and stimulant in the catecholaminergic psychedelic class also known as phenylethylamine psychedelics and amphetamine stimulants. MDMA works by increasing synaptic concentration of serotonin, norepinephrine, and to a lesser extent, dopamine. When the MDMA molecule crosses the blood brain barrier the chemical is shaped similar enough to serotonin to enter a serotonin transporter. Then the MDMA molecules inhibit the vesicular monoamine transporters (VMAT) which causes serotonin to be rapidly released from the vesicles housing it and accumulates in the cytosol. Finally, MDMA changes the direction of serotonin transporters to release excessive amounts of serotonin out of the neuron which floods into the synaptic cleft. Serotonin reuptake is inhibited and leaves massive amounts of serotonin in the synaptic cleft to stimulate serotonin receptors continuously causing them to fire. MDMA mechanism in the brain

  • How does DMT work in the brain | Drug Speak

    Learn how DMT effects the brain from a simplified neuroscience perspective. DMT pharmacology Serotonin molecule 5-hydroxytryptamine DMT molecule dimethyltryptamine 5-hydroxy signifies the OH group on the left side of the image dimethyl signifies both CH3 groups (methyl groups) on the NItrogen (N) DMT stands for N,N-dimethyltryptamine DMT Main page still in development still in development Next page dmt pharmacology

  • Creator info | Drug Speak

    Learn about the creator of DrugSpeak. Why does drugspeak.org exist and what is it. Author information Mission & Goals My name is Kevin and I am the sole creator of Drugspeak.org. I am currently pursuing my bachelors in behavioral neuroscience at Florida State University. I believe there is a lack of easily accessible information on true unbiased science behind drugs on the internet. Drug Speak delivers reputable and up-to-date information on current drug research. My aim is to distribute information without political or economic bias to provide the researched-based understanding of drugs. Become a DrugSpeak Member X (Twitter) Follow me! @DrugSpeak_org Enter your email here Sign Up Thanks for submitting!

  • Learn how to use cocaine safely | DrugSpeak

    Learn about dosing, purity, and effects of cocaine. General Cocaine info Cocaine also known as coke, blow, and snow, is a stimulant powder that is inhaled through the nose (aka snorting). Cocaine has 2 common forms: powder that is snorted, and the crystal rock version called crack that is smoked. Both cocaine and crack contain the same psychoactive chemical. Snorted cocaine increases heart rate, blood pressure, and boosts general energy. Within a couple minutes of ingestion, the user feels a rush of euphoria and energy kick that feels very sharp and pleasurable. Many users often feel like they are stronger than they are, more confident, and more energetic. Users often speak quicker and move their body more via fidgeting or dancing if in a party or bar setting. Cocaine has a similar feeling to Adderall but much less duration and cocaine’s effects are felt much quicker than an Adderall pill. Cocaine Q&A pharmacology Cocaine is extracted from these leaves called Coca leaves It is critical to reagent test MDMA. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe cocaine vs crack How to dose cocaine How illegal is cocaine? Americans often view cocaine as a “high class” drug because of its high cost and history related to celebrities and wealthy people who use it. Many people believe that cocaine is a rich people’s party drug but crack is a drug that brings images of homelessness, addiction, hopelessness. This societal view is very dangerous as it downplays the dangers of cocaine use. It must be understood that powder cocaine and crack provide the exact same high and carry the same general dangers. The only difference between the two is that crack is smoked therefore the high feels more like a “rush” and effects are felt very quickly within 20 seconds. Cocaine Is snorted so the effects take a couple minutes to be felt which decreases the sense of quick euphoria. It is true that the rushing euphoria of crack is more psychologically addictive but both cocaine and crack have the exact same overall high. After all, crack is just powdered cocaine cooked together with baking soda to turn it into a crystal. American society has an inaccurate perception that cocaine is more socially acceptable than crack. Cocaine is an illegal Schedule 2 drug in the United States. Schedule 2 drugs are considered to have high potential for abuse with use potentially leading to severe psychological or physical dependence. The scheduling of a drug is determined by the Drug Enforcement Administration (DEA) in America. Other Schedule 2 drugs include Adderall, methamphetamine, and oxycodone, and fentanyl. The scheduling of drugs in America is very controversial and the ranking does not always align with the current scientific research regarding the danger and abuse potential of the substances. A dose of cocaine is often described one of two ways: bumps and lines. A “bump” is a smaller dose than a line where someone uses a tool like a key to pick up a little pile of powder and snorts it. The other way is a line where a larger dose of cocaine is placed on a surface like a table and snorted along the length of the line. The weight of a bump or line cannot be recommended because the purity of different people’s cocaine will be different. A 10 milligram bump of 100% pure cocaine is 4 times as strong as 25% pure coke so there really is no average size dose of cocaine. As a rough guide, always assume your cocaine is really strong so you do not underestimate it and take too much. Both powder cocaine and crack cocaine are very hard to dose correctly. Many factors such as purity, other adulterants (laced) or inaccuracies in weighing all make a recommendation for dosing extremely difficult. Since Cocaine is just a generic looking white powder it is nearly impossible to understand what the powder is made of by taste or smell alone. It is always urgently recommended to reagent drug test your substances before use. In America, Cocaine is heavily adulterated and cut with chemicals to thin it out or laced with other drugs to enhance the effects. Inactive ingredients like baking soda, baby powder, creatine, or lidocaine/ procaine, or a number of others are almost always added before a customer receives it. While active ingredients are less frequent it is adds risk and harm potential, cocaine is sometimes cut with caffeine, meth, and even opioids like heroin or fentanyl. Since all the inactive and active ingredients listed above could be generic white powders you can never be sure what is in cocaine. Pure cocaine and lethal dose fentanyl laced powder look the exact same. Furthermore, when adulterants are mixed with cocaine, most cutting agents are odorless so both look and smell are not able to be noticed. Fentanyl, caffeine, meth, are odorless when mixed with cocaine so a white powder called cocaine can really be made of anything. Cocaine is produced majorly in south America then trafficked to everywhere else in the world. Countries like Colombia, Bolivia, and Peru all have a monopoly on the cocaine production market. Cartels within those countries account for nearly 100% of the cocaine produced and distributed around the world. Although, cocaine in those countries is produced pure without adulterants, once that pure powder gets trafficked to another country the drug is cut and altered each time it changes hands. While America and Europe are both different distances from South America, the cutting agents used are largely the same. These substances include acetaminophen, phenacetine, caffeine, lidocaine and in almost 70% of the samples levamisole (363 out of 524 samples) dangers of Mixing cocaine and alcohol Cocaine is often a party drug used at clubs, festivals, and parties. Partiers that drink alcohol often use cocaine at the same time to diminish the sedative effects of alcohol and make them more alert. Mixing cocaine with alcohol is dangerous for many reasons. Firstly, alcohol is a depressant and cocaine is a stimulant so mixing them can make the user feel more sober than they actually are. Cocaine use while drinking can make someone feel as if they can drink more without getting sick or “blacking out.” This makes alcohol poisoning and injury from falling much more likely. Secondly, mixing cocaine and alcohol creates a very unique chemical reaction in the body. Mixing these drugs creates the psychoactive chemical cocaethylene in the body. Cocaethylene causes the euphoric effects of cocaine to increase and create severe toxicity in the cardiovascular system. Since alcohol is a depressant it causes the cardiovascular system to relax and dilates blood vessels including the vessels in the nose. Dilated nose blood vessels means that more of the cocaine snorted will reach the blood stream and heighten the drug effects even more. Cocaethylene is extremely toxic and more damaging than either cocaine or alcohol by themselves. The damage caused by alcohol plus cocaine plus cocaethylene makes this drug combination one of the most dangerous and toxic there is. cocaine main page toxicity and overdose potential of cocaine Cocaine overdose is quite common for a multitude of reasons. Coke is a strong nervous system stimulant which ramps up heart rate, metabolism, temperature, and blood pressure. If too much cocaine is consumed the spike in bodily functions may cause overexertion of organs causing heart attack, overheating (heat stroke), lung problems like pneumonia, and sleep deprivation in chronic users. Seizures are also possible due to cocaines stimulating effects in the brain. Cocaine outside of production countries such as Bolivia and Colombia is often cut with various things to mimic the effects of cocaine or thin the drug out. Everything from baby powder to lidocaine to fentanyl can be mixed into cocaine powder because all those substances are white powders visually identical to the pure drug. As with every other drug, it is heavily recommended to reagent test the substance to identify the chemicals and drugs it is made of. Reagent testing kits are fairly inexpensive yet they can save your life and spare your from ingesting a drug laced with something deadly like fentanyl. The Marquis and Liebermann reagent tests are recommended for cocaine testing. The marquis reagent can identify cocaine mixed with amphetamines Morris, Marquis, and Liebermann reagents. These kits that are capable of detecting specific cuts (levamisole and lidocaine) It is critical to reagent test Cocaine. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe How to reagent test Cocaine Reagent testing cocaine step 1 Morris reagent Real cocaine causes a blue color when it comes in contact with the morris reagent Any other color besides blue indicates the powder may be laced with another drug. Morris reagent is a 2 step process with 2 liquids used at the same time on the same sample. Reagent testing cocaine step 2 Marquis reagent This reagent does not confirm the sample is cocaine. It is meant to show you possible drugs laced into the powder. The marquis reagent must be used with step 1 and 3 to be confident. Reagent testing cocaine step 3 Liebermann reagent Real cocaine causes a yellow tan color Note that ketamine also has the same color. The Morris reagent (step 1) can distinguish ketamine from cocaine. Final Step ALWAYS USE A FENTANYL TESTING STRIP Use a fentanyl test for every drug you intend to take. it will save your life.

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