Learn how cocaine effects the brain from a simplified neuroscience perspective. How cocaine works in the brain cocaine main page cocaine molecule Cocaine hydrochloride (powder) is a catecholamine-like monoaminergic stimulant that blocks the reuptake of dopamine, norepinephrine, and serotonin. Cocaine’s molecular structure is chemically similar to endogenous dopamine. Similar structure causes the chemical to bind to dopamine transporters of dopaminergic terminals to blocks reuptake of DA, NE, and 5-Ht. The dopamine spike results in euphoria, hyperactivity, and increased focus. This quick dopamine hit gives cocaine its addiction potential as insufflation (snorting), injection, and smoking all deliver a fast rush of euphoria and energy which can cause psychological dependency. Norepinephrine (noradrenaline) also increases sharply from cocaine ingestion which results in potentially dangerous heart rate increase, vasoconstriction, and tremors. The sharp Noradrenaline spike also contributes to the intensity of the initial “rush” quickly after ingestion. Next page Cocaine as an anesthetic Cocaine is also an anesthetic similar to lidocaine which can numb anything the powder comes in contact with like nose, skin, mouth, and lung. Cocaine acts as an anesthetic because it blocks voltage gated sodium ion channels in nerve cells which increases the action potential threshold and slows the rate of depolarization. These shifts in action potential function makes physical sensation signals much less prevalent in the nerve cells cocaine touches.

Learn about Amphetamines, the dose, purity, effects, and how they work in the brain How to safely use meth and adderall (amphetamines) Meth & adderall Q&A Drugs list Amphetamine pharmacology Amphetamines are a group of stimulant drugs including Meth and Adderall. There are thousands of drugs in the amphetamine class but these 2 are the most prevalent in society. Methamphetamine and amphetamine salt (Adderall) yield extremely similar effects and carry similar risks when consumed in recreational doses. Note that any information written about ADDERALL refers to those who abuse and get high on it. Prescribed amounts for those who need the drug are not included in this article. People with ADHD taking prescribed 5mg to 20mg of Adderall are not the same as an average person snorting (sniffing) many crushed up pills to get high. Methamphetamine is also known as meth, crank, ice, crystal. Adderall is sometimes called a smart drug or study drug. Methamphetamine is illegal in all circumstances whereas Adderall can be legally prescribed for the treatment of disorders like attention deficit hyperactivity disorder (ADHD). Both drugs are central nervous stimulants or “uppers” that induce euphoria, explosive amount of energy, increase enthusiasm, ramp up heart rate, and constrict pupils / circulation. High doses of these drugs lessen the desire for eating or sleeping which has many mental and bodily consequences. The Amphetamine class of drugs used recreationally cause the user to feel stronger, more confident, smarter, and more aware then they really are. how illegal is meth / adderall meth & adderall myths The general population views meth as a hard drug that is highly addictive and ruins the life of everyone who uses it. Someone imagining a meth addict visualizes a bone skinny, raggedy, toothless, dirty homeless person. Meanwhile, when someone visualizes an Adderall user they often visualize a businessman taking drugs to manage their busy work or busy family schedule. Put simply, meth is viewed as a dangerous drug that ruins lives and Adderall as a drug used for studying and productivity for normal people. The truth, according to pharmacology, is that pure meth and Adderall are just as addictive and relatively the same danger level to consume when taken at the same dose. Both meth and Adderall equally cause sleep deprivation, weight loss, dopamine deficiency, and brain alterations. Both chemicals function the same way in the brain and carry extremely similar overdose potential. Society is mislead because meth is illegal and Adderall is a “medicine” so it is reasonable to believe that a medicine is good for you and illegal drugs are dangerous. Sadly, this is not the case. Adderall (dextro and levoamphetamine) is not a better or worse choice to make legal than using medical grade methamphetamine. The one and only reason Adderall may be considered a better option to use recreationally is because pills from a pharmacy are not likely to be laced, have impurities, and have accurate dosing. Theoretically, if you have 2 pills, one contains meth and the other contains Adderall amphetamines. Assume both are medical grade and contain no harmful additives. It would be impossible to tell which pill contains what based solely off of the effects of the drug. The only way to tell is if you test the pill with a reagent testing kit. Overall, it is highly recommended to learn about drugs on your own and not believe that legal medicines are always good and illegal drugs will always kill you. Adderall and meth are effectively the same drug with totally different public perceptions. Methamphetamine and Adderall are both Schedule 2 drugs in the United States. Schedule 2 drugs are considered to have high potential for abuse potentially leading to severe psychological or physical dependence. The scheduling of a drug is determined by the Drug Enforcement Administration (DEA) in America. Other Schedule 2 drugs include cocaine, Ritalin, oxycodone, and fentanyl. The scheduling of drugs in America is very controversial and the ranking does not always align with the current scientific research regarding the danger and abuse potential of the substances. Adderall dosing Instant release Tablets made of pressed powder effects last 4 to 6 hours usually lower dosages (5mg to 15mg) but sometimes higher dosages (30mg) Extended release capsules capsule full of amphetamine beads effects typically last 8 to 12 hours, possibly longer Higher dosages (20mg to 30mg) Adderall is available as either colored, stamped pills or orange capsules with beads. Pills provide immediate effects within an hour, while capsules offer extended release over 6urs. Some abuse Adderall by crushing snorting it, seeking a quicker rush of euphoria, which is dangerous. Snorting can harm the nose and respiratory system, as the fillers are not meant for inhalation, and it increases the drug's addictive potential due to the rapid onset of effects. Meth dosing Methamphetamine is often found in powder or crystalized form. Powder meth is often snorted, injected, swallowed in capsules. Whereas crystal meth is not snorted because it severely cuts and tears the inside of the nose. Crystal can be smoked, melted then injected, or swallowed. Due to meth being illegal and not created by a regulated company the ingredients in meth are unknown. It is recommended to swallow meth opposed to snorting, smoking, and definitely avoid injecting. Making meth includes using extremely toxic chemicals like strong acids, phosphorous and many dangerous chemicals that can damage your nose, lungs, and veins. It is extremely recommended to never do meth in any form but if you do meth it Is extremely recommended that swallowing an ACCURATELY WEIGHED small dose is the best way to avoid excess damage to internal organs. Administering meth in other ways than swallowing can lead to damage to nasal cavities, lungs, teeth, throat, and veins. The phrase “meth mouth” exists because people who smoke meth for a long time have severe tooth and gum damage. The actual methamphetamine drug itself does not cause mouth damage. It is the toxic additives that are leftover from creating the drug. How to remain safe using street Adderall Street Adderall are very commonly counterfeited, laced with meth or other drugs, and can contain the wrong dose. These risks apply to Adderall pills not from a pharmacy / prescription. The rule of thumb is if you did not personally pick them up from the pharmacy with your prescription then you MUST assume they are counterfeit. Never believe a dealer that say they got them from a pharmacy even if they show you a prescription. Always assume a dealers drugs will be laced . Dealers and producers can buy amphetamine powder and a pill press machine from amazon to make pills that looks identical to a real pharmaceutical grade pill. Do not try to visually distinguish real from fake pills. Additionally, if you test your Adderall and it tests positive for the correct drug, you can never know how much of the drug is in the pill. Never blindly believe the pills label If its stamped “30” or “15” indicating the amount of milligrams. Counterfeit dealers often press an incorrect amount of the amphetamine powder into the pill. There is not a test to determine how strong the pill is so after reagent testing the pill , it is recommended to swallow 10% of the pill to gauge how strong it is. Counterfeit Adderall often contain no Adderall at all. Many pills are made with powdered methamphetamine mixed with colored pill binder and pressed into the shape and color of real pills. Dealers can make more money selling meth and calling it Adderall. If you get Adderall pills from anywhere besides a pharmacy with your prescription you MUST reagent test the drug to make sure your pills are not methamphetamine. Many websites sell the test kits can decipher Adderall from meth It is critical to reagent test meth / Adderall. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe How to test if your Adderall is real Step 1 Buy the marquis OR Liebermann reagent. Either of these tests will turn orange when EITHER meth or Adderall is detected. The marquis / Liebermann test will tell you if you have a type of amphetamine and not a completely different drug like heroin or MDMA. Only Meth and Adderall turn orange when using this test. Step 2 Buy the Simon’s reagent to see if you have meth OR Adderall. When placing a drop of the simons reagent on a small portion of the pill, the reagent will turn blue if the pill is made of meth and have no reaction if the pill is Adderall. step 3 You must use a fentanyl contamination test. As little as 2 grains of sand worth of fentanyl can be deadly. This step is as important as the previous 2 steps. Information to note YOU MUST UNDERSTAND that both marquis OR lieberman in addition to simons need to be used. Using only 1 reagent and not the other will not give you enough information to confidently say the pill is meth or Adderall. After both steps of reagent testing it is likely that the results from the reagents determined the correct drug.

Learn LSD pharmacology from a simplified neuroscience perspective. Pharmacology of LSD Learn how LSD works in the brain from a molecular perspective Main LSD page Lysergic acid diethylamide (LSD) is a monoaminergic psychedelic with a chemical structure very similar to the neurotransmitter serotonin. Upon consumption, the LSD molecule crosses the blood-brain barrier and binds to 8 different serotonin receptors mainly the 5HT2A receptor. LSD binding agonizes (binds to) this receptor and causes an increase in 5HT2A serotonin firing. The proposed reason for LSD's lengthy duration is due to the formation of a "lid" on the serotonin receptor. It is believed that the LSD molecule creates a type of lid that hinders the reuptake of the molecule, making it more difficult for it to be broken down and removed from the serotonin receptor. This prolonged interaction with the receptor contributes to the extended effects of LSD compared to endogenous (naturally occurring) serotonin. Next page LSD analogues (drugs similar to LSD) LSD is illegal and completely unregulated since it is produced and distributed illegally the purity, dose, and substance is unknown when dealing with LSD. When people say LSD they mean the chemical Lysergic acid diethylamide. There are many analogues of LSD that are known and being researched. A drug analogue is a chemical that looks and behaves very similarly to another chemical while having very slight differences . For example, Lysergic acid diethylamide (LSD) has a very similar chemical called 1p-LSD. The 1p-lsd molecule looks nearly identical to someone without a background in chemistry but there is a slight difference between LSD and 1p-LSD. Both chemicals are psychoactive and cause psychedelic effects but LSD is schedule 1 illegal and 1p-LSD is considered a research chemical and not directly illegal. The Federal analogue act of 1986 in the United States stated that a chemical that is substantially similar to an illegal drug should be considered illegal as well but only if the chemical is intended for human consumption. Some research companies in Canada legally distribute analogues of LSD such as 1p-LSD, 1b-LSD, 1v-LSD. All these chemicals are very similar to LSD but not exactly the same. There are definitely differences between them but they are all psychedelic and are measured in microgram doses similar to Lysergic Acid diethylamide (regular LSD). (both tabs contain 1p-LSD) Sometimes analogues are on labeled blotter paper. Most analogues are meant to trick buyers into thinking it is real LSD. 1-propanoyl-lyserigic acid diethylamine Fun fact LSD was made on accident by Swiss scientist Albert Hoffman in 1943. He dosed himself by mistake and experienced the first LSD trip ever! ALBERT HOFFMAN: THE CREATOR OF LSD

Discover dimethyltryptamine effects and guidelines for safe use. Learn about DMT's impact on the brain and safety precautions. Pharmacology DMT Q&A DMT is often called “the spirit molecule” It is thought to be the most potent psychedelic drug known to science. DMT induces full out of body experiences known as ego death where the ability to realize you are alive or have lived is lost. DMT safety and dosing DMT stands for Dimethyltryptamine and 5-MeO-DMT is 5-methoxy-dimethyltryptamine. DMT is much stronger and lasts much less time than other psychedelics like LSD or mushrooms. The dosing guidelines provided below are for smoking DMT. Disclaimer: the dosage guidelines provided are extremely rough estimates and are not concrete. Variables such as purity, person's weight, and brain chemistry differences can all affect how DMT affects you at a certain dose. Use the dosages provided as a general idea and ALWAYS START SMALL and work your way up. There are defined levels and terminology for DMT trips. The difference between 30 and 40 mg of DMT powder causes a much stronger experience and is not noticeable to the naked eye. You must use a high quality milligram scale to safely dose this drug. DMT is often sold as a crystal or powder and is often smoked. Many people choose to put DMT onto marijuana and smoke it but that is not recommended as mixing marijuana with psychedelics raises the chances of having an overwhelming trip. DMT crystals are can be completely white but impurities in powders can cause an off-white, yellow, or light brownish color which is normal. Smoked DMT powder is often described as smelling and tasting like rubber or mothballs which is very distinct from any other smell. ayahuasca Dosing Pure DMT How illegal is DMT Ayahuasca is a brewed liquid traditionally from root bark and plants that contain DMT. Ayahuasca has a long history of use by South American religious groups as a sacred ritual where ayahuasca (DMT) drinks are consumed to cause psychedelic and spiritual experiences. The word ayahuasca is the name of a vine from the Amazon that contains DMT. While there are many plants used for ayahuasca a popular source of DMT is from the root bark of the plant Mimosa Hostilis. Mimosa Hostilis root bark is boiled which extracts the DMT from it. Drinking DMT root bark tea by itself will not give psychedelic effects. DMT is not an orally active molecule which is why the powder is often smoked. To make DMT tea orally active there must be a Monoamine oxidase inhibitor (MAOI) present. The liver enzyme Monoamine Oxidase breaks the DMT molecule down into a non-psychoactive derivative before it has a chance to cause psychedelic effects. Many metabolites are produced from DMT break down but mainly DMT-N-oxide (DMT-NO), and indole-3-acetic acid (IAA) which are not hallucinogenic. To prevent DMT breakdown in the liver the monoamine oxidase (MAO) must be blocked by way of a monoamine oxidase inhibitor (MAOI). Many ayahuasca brews contain both a bark like Mimosa Hostilis and a plant containing MAOIs such as Banisteriopsis caapi (BC) and Peganum harmala (PH). Both MAOI plants contain an active monoamine oxidase inhibitor such as β-carbolines harmalol, harmine, and harmaline. By brewing a DMT-containing bark like Mimosa Hostilis and MAOI-containing plant such as Peganum harmala together the resulting brew will cause hallucinogenic DMT effects when consumed. DMT containing plants such as Mimosa hostilis root bark are usually legal to purchase and possess in the united states. Although pure DMT powder is a schedule 1 illegal drug there is a grey area in the law about the entire plant. Purchasing and possessing the plant or bark is legal while extracting and consuming DMT is illegal. DMT is an illegal Schedule 1 drug in the United States. Schedule 1 drugs are considered to have no medical benefits and high potential for abuse. The scheduling of a drug is determined by the Drug Enforcement Administration (DEA) in America. Other Schedule 1 drugs include heroin, marijuana, and ecstasy (MDMA). The scheduling of drugs in America is very controversial and the scheduling does not always align with the current scientific research regarding the danger and abuse potential of the substances. DMT containing plants such as Mimosa hostilis root bark are usually legal to purchase and possess in the united states. Although pure DMT powder is a schedule 1 illegal drug there is a grey area in the law about the entire plant. Purchasing and possessing the plant or bark is legal while extracting and consuming DMT is illegal. An effective dose of DMT is very small and extremely potent so accurate measuring is crucial. You must use a scale that measures milligrams accurately and reliably. The average dose of smoked crystal (freebase) DMT is anywhere from 20 to 40 milligrams or 0.02 to 0.04 grams. Anything above 40 milligrams has a high chance of overwhelming the average person. DMT doses are so small that you must weigh them with a precision scale to remain safe and in control of your dose. For perspective, 50 milligrams is about how much a grain of rice weighs which is very small. Warning DMT carts are easily laced with deadly drugs like fentanyl. carts are the most dangerous way to ingest DMT How Ayahuasca is made Mimosa hostilis root bark DMT containing root bark is shredded and boiled to extract the psychedelic component Banisteriopsis caapi vine A monoamine oxidase inhibitor (MAOI) containing vine or bark is boiled with the DMT containing source to make the DMT orally active so psychedelic effects to occur when the brew is consumed Final product: ayahuasca The final brew contains orally active DMT which causes intense psychedelic effects when drank.

Discover how MDMA affects the brain with insights into serotonin neurotransmission and its impact on the nervous system. MDMA Pharmacology MDMA Home page MDMA standing for Methylene-dioxy-methyl-amphetamine acts both as a psychedelic and stimulant in the catecholaminergic psychedelic class also known as phenylethylamine psychedelics and amphetamine stimulants. MDMA works by increasing synaptic concentration of serotonin, norepinephrine, and to a lesser extent, dopamine. When the MDMA molecule crosses the blood brain barrier the chemical is shaped similar enough to serotonin to enter a serotonin transporter. Then the MDMA molecules inhibit the vesicular monoamine transporters (VMAT) which causes serotonin to be rapidly released from the vesicles housing it and accumulates in the cytosol. Finally, MDMA changes the direction of serotonin transporters to release excessive amounts of serotonin out of the neuron which floods into the synaptic cleft. Serotonin reuptake is inhibited and leaves massive amounts of serotonin in the synaptic cleft to stimulate serotonin receptors continuously causing them to fire. MDMA mechanism in the brain

Find accurate drug information online with DrugSpeak. Learn about drugs' effects, safety tips, and more. Drug Testing kits Read more Psilocybin Mushrooms Read more LSD Read more DMT Read more MDMA & Ecstasy Read more Cocaine Read more Meth & Adderall Read more Common Questions Quick answers

Discover the effects of LSD, its safety tips, and how it works in the brain. Learn essential facts about the effects of LSD today. LSD LSD, also known as Acid & Lucy, is a very potent psychedelic drug that causes visual hallucinations and alters perception and mood. The acronym LSD stands for Lysergic acid diethylamide. LSD effects are similar to psilocybin mushrooms (magic mushrooms), as they both mimic the brain chemical serotonin. the duration of the trip lasts approximately 6 to 10 hours with the strongest effects occurring at 3 hours after ingestion. Pharmacology LSD tab dosing How to dose correctly What does LSD feel like? To safely ingest LSD it is crucial to understand that it is very potent even in low doses. A typical dose of LSD is 100 micrograms which is equivalent to 0.1 milligrams or roughly the size of a grain of sand. One tab can contain anywhere from 1 microgram to 500 micrograms. It is difficult to determine the correct dose of LSD because a couple grains of sand worth of LSD can turn a normal dose into an extremely strong one. Doses are sold in various forms including, blotter paper, gelatin tabs, or crystal LSD dissolved in alcohol known as a “vial.” It is not possible to precisely know how many micrograms are on a tab without lab testing so it is critical to take a test dose. Microdosing 1/20th to 1/10th of a tab no psychedelic (visual) effects but minor mood lifting may occur. The microdose level should only influence subconscious emotion, thinking, and perception. Many believe microdosing increases both productivity and creativity and has anti-depressent effects. The benefits are being researched but no definitive conclusions about risk and reward can be given without thorough research. Very low dose (1/10th to 1/5th of a tab Minor psychedelic (visual) effects may or may not occur. Colors may seem brighter and surfaces may have moving patterns covering them. Mood should be noticeably altered with increased deep thought and noticing details, colors, and surroundings like nature may be much different than sober perceptions. Low to moderate dose (1/4 to 1/5 of a tab) Effects will become very noticeable above a quarter tab. visual hallucinations like colors and patters will become apparent and increase in intensity as the dose increases after .25 tabs. Wonder filled thoughts and feelings of stimulation begin to intensify at this dose. Mood can increase with feelings of exitement and slight euphoria. Even a low dose can cause anxiety and sometimes fear if your mindset and location are not correct. Tripping in a very public place like a concert or crowded beach are more likely to cause anxiety compared to a calm house or soothing nature. normal dose (full psychedelic trip) 1 full tab 1 tab is designed to be the perfect dose for full psychedelic effects while usually remaining controllable and not too intense for. at 1 full tab the colors and patterns are very apparent and occur when eyes are both open and closed. Objects often “breath” which means swaying and bending in a magical type way. You may notice the floor, walls, trees, hands, and surfaces sway and have patterns overlayed on them. Vibrancy of colors is heightened and closed eye visuals contain all colors of the rainbow that create complex shapes and infinite kaleidoscopic patterns. Intense feelings of stimulation and alertness. Even though 1 tab is an average dose for a full trip there is still a chance that paranoia or anxiety can occur. The best way to prevent them is to take LSD with people you trust in a place that makes you calm / comfortable Very heavy dose (greater than 1 full tab) heavy doses above 1 full tab are very potent and marks the point where bad trips become more likely. The effects of 1.5 to 3 tabs may be much too intense for any beginner or even experienced people. At this dose the psychedelic visuals may distort and fill vision so intensely that it is difficult to see straight and identify things around you which is very dangerous. Thought loops are very common at these doses and negative loops including terror, paranoia, and detachment from reality may be overwhelming and cause outbursts or extreme confusion. It is critical to have someone you trust who remains sober to keep you safe on a dose that large. Ego death is possible when many tabs are taken at once. Ego death is when the trip is so strong you forget that you are alive and is similar to being in a trance. Time and reality and shattered and your actions and behavior may be out of your control. It is extremely risky to experience ego death alone, with strangers, or anywhere in public. To test the strength of a tab, it is advised to start by ingesting 10% of a tab to gauge the strength. 10% of a normal 100 microgram tab should not cause any visual distortions whatsoever. You may experience slight mood changes but such a low dose should cause very minimal noticeable effects. If visual effects are noticeable with 10% of a tab then the tab is much stronger than a standard dose. Once a low dose is tested you can help prevent taking too much in the future. If you are confident that 10% of a tab is not strong then slowly start increasing amount of dose up to a full tab. LSD can be absorbed in the mouth or digested in the stomach. The most effective method of ingestion involves placing the tab underneath the tongue then swallowing the paper 15 minutes later. Alternatively, the tab can be swallowed immediately but the psychedelic effects may be delayed a bit longer than the under the tongue method. After ingesting the tab, the effects should begin within 45 minutes. If there are no effects at all within 1.5 hours the tab is either very weak or did not contain LSD at all. DO NOT take another tab unless at least 2.5 hours have gone by with zero effects. You do not want to take another dose before the last one has gotten the full amount of time to onset. LSD Q&A Onset – occurs within an hour Intensity increase – hour 1 to 3 Peak - (strongest effects) – 3 hours after ingestion Come down - (effects slowly waring off) hour 4 to 8 "afterglow” - (lingering positive mood) – can last for 2 to 8 hours after effects have worn off How to see if your LSD is real It is critical to reagent test LSD. Please visit Dance Safe linked below and get drug testing kits. It may save your life. Click here to get reagents on Dance Safe Reagent testing LSD step 1 Ehrlich reagent Real LSD causes a purple color when it comes in contact with the Ehrlich reagent Any other color besides purple indicates the tab does not contain LSD and may be laced with a different drug It is critical to reagent test your LSD to confirm you have the correct drug. Reagent testing LSD is extremely recommended because it can save your life. The “Ehrlich” reagent test is the preferred test for LSD. The Ehrlich reagent kit will reliably test blotter tabs of LSD. The Ehrlich reagent works by placing one drop of the reagent on about 1/20th of a blotter tab. The reagent reacts with the chemical on the tab and changes colors based on the chemical reaction. If the LSD is real then the Ehrlich reagent will yield a purple color within 5 seconds to 5 minutes. If there is no color or anything different than purple you cannot be certain your tab contains LSD and you should throw the tabs away. Reagent testing LSD step 2 Hoffman reagent Real LSD causes a blue color when it comes in contact with the Hoffman reagent NBOMe drugs are an LSD imposter substance that can kill you. Make sure the color is not yellow or amber colored. Those colors indicate a drug different than LSD and may be NBOMe drugs. (See 25D and 25B NBOMe in the image to the right). You must use the Hoffman reagent as well to test tabs. Hoffman reagent can detect the difference between real LSD and different variants of NBOME. The Hoffman reagent yields a blue color when it touches real LSD and different types of yellow or pink for other substances like 25i-nbome, 2c-I, and 25B-NBOME. There are similarities and very important differences between LSD and NBOME. LSD dose ranges from 40 micrograms (low) to 250 (high) with the average being 100 to 150 micrograms. Whereas NBOME doses are mild at 250 to 450 micrograms high doses are around 450 to 800 micrograms. The dosages between LSD and NBOME seem different in numbers but the difference of 200 micrograms to 600 is extremely small to the naked eye. Since it is nearly impossible to visually distinguish how much of a drug is on blotter paper or in a vial or gelatin tabs it is best to test the substance with an Ehrlich reagent kit. LSD by itself can not kill you by overdose but NBOME can kill you very easily. The worst that can happen in a high LSD dose is terror, anxiety, and confusion. But you will live and not experience noticeable brain damage even in extremely high doses. On the other hand, NBOME compounds can directly kill you LSD in any form like blotter paper, gelatin tabs, or liquid in a vial is tasteless and odorless. An LSD dose cannot be visually measured because 100 micrograms is microscopic. It is essential to be aware that street dealers may sell dangerous counterfeit substances presented as LSD. For instance, the psychedelic compound 25I-NBOMe is sometimes passed off as acid. However, NBOMe compounds are much more harmful than LSD, only a few grains of salt worth of NBOME compounds can lead to severe health complications, including heart failure, seizures, and death. LSD doses typically range from 40 micrograms (low) to 250 micrograms (high), with the average dose falling between 100 to 150 micrograms. In contrast, NBOMe doses are considered mild at 250 to 450 micrograms, with high doses reaching around 450 to 800 micrograms. While the microgram gap may seem large, in reality, a difference of 300 micrograms is extremely hard to visually notice while being much more powerful. Given that visually determining the quantity of a substance on blotter paper, in a vial, or gelatin tabs is virtually impossible, it is highly recommended to test the substance using an Ehrlich reagent kit. NBOMe compounds have the potential to cause lethal consequences. The lethal dose of NBOMe can be as little as 2 milligrams (2000 micrograms), which is a minuscule amount. What is LSD tolerance? LSD often carries misconceptions and negative stigma in the public eye. While all psychoactive substances carry risks, the level and nature of the risk vary between different drugs. LSD is widely recognized as having a very low potential for addiction. The low addiction risk is due to the unique tolerance built for LSD when used consistently. When is LSD used more than once a week tolerance builds up quickly, requiring higher doses to achieve the same effects. For example, if someone takes a 100 microgram tab of LSD every day for a week, by the seventh day, that same 100 microgram tab would have significantly diminished psychedelic effects, perhaps feeling like only 1.5 micrograms which has zero psychedelic effects. The drastic drop in effect makes LSD nearly impossible to become addicted to because you have to increase the dose to absurd levels. After a week of everyday use, someone would have to consume 128 tabs to feel average psychedelic effects. The number of LSD needed to be consumed is doubled each consecutive day it is used which makes the likelihood of someone becoming addicted to LSD extremely low. Similarly, there have been zero reliably recorded cases of LSD overdose caused solely by LSD in those without prior medical conditions or mixing other substances with LSD. 100 LSD gel tabs Gel tabs come in many different colors and shapes Color or shape do not indicate strength or purity 100 LSD blotter tabs Blotter tabs can have infinite amount of designs. The design does not indicate strength or purity

Discover everything about drug testing reagents. Learn how to use drug testing reagents effectively to ensure safety. Marquis Reagent 101: The ultimate guide to MDMA, Meth, and Opiate testing With the rise of designer drugs and research chemicals in social settings, it is crucial for users to know exactly what substances they... Ehrlich Reagent 101: The Ultimate Guide to the LSD test kit Learn how the Ehrlich reagent test kit identifies psychedelic drugs

Discover the effects of ayahuasca, a brew containing DMT and monoamine oxidase inhibitors, and learn about its cultural uses and safety. Ayahuasca DMT home page Ayahuasca is a brewed liquid traditionally from root bark and plants that contain DMT. Ayahuasca has a long history of use by South American religious groups as a sacred ritual where ayahuasca (DMT) drinks are consumed to cause psychedelic and spiritual experiences. The word ayahuasca is the name of a vine from the Amazon that contains DMT. While there are many plants used for ayahuasca a popular source of DMT is from the root bark of the plant Mimosa Hostilis. Mimosa Hostilis root bark is boiled which extracts the DMT from it. Drinking DMT root bark tea by itself will not give psychedelic effects. DMT is not an orally active molecule which is why the powder is often smoked. To make DMT tea orally active there must be a Monoamine oxidase inhibitor (MAOI) present. The liver enzyme Monoamine Oxidase breaks the DMT molecule down into a non-psychoactive derivative before it has a chance to cause psychedelic effects. Many metabolites are produced from DMT break down but mainly DMT-N-oxide (DMT-NO), and indole-3-acetic acid (IAA) which are not hallucinogenic. To prevent DMT breakdown in the liver the monoamine oxidase (MAO) must be blocked by way of a monoamine oxidase inhibitor (MAOI). Many ayahuasca brews contain both a bark like Mimosa Hostilis and a plant containing MAOIs such as Banisteriopsis caapi (BC) and Peganum harmala (PH). Both MAOI plants contain an active monoamine oxidase inhibitor such as β-carbolines harmalol, harmine, and harmaline. By brewing a DMT-containing bark like Mimosa Hostilis and MAOI-containing plant such as Peganum harmala together the resulting brew will cause hallucinogenic DMT effects when consumed. DMT containing plants such as Mimosa hostilis root bark are usually legal to purchase and possess in the united states. Although pure DMT powder is a schedule 1 illegal drug there is a grey area in the law about the entire plant. Purchasing and possessing the plant or bark is legal while extracting and consuming DMT is illegal. Mimosa hostilis root bark (contains DMT) Banisteriopsis caapi vine (contains MAOI inhibitor) Finished product: ayahuasca brew (contains DMT and MOAI inhibitor)

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